Trial reportCanadian journal of gastroenterology = Journal canadien de gastroenterologie2006
Helicobacter pylori eradication with either 7-day or 10-day triple therapies, and with a 10-day sequential regimen.
Trial report in Canadian journal of gastroenterology = Journal canadien de gastroenterologie, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01273441 (Phase 4, Prospective, Randomized and Comparative Study Comparing Sequential and Concomitant Therapy for Helicobacter Pylori Eradication in Routine Clinical Practice), which is not on this map. Cited by 20 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Phase 4, Prospective, Randomized and Comparative Study Comparing Sequential and Concomitant Therapy for Helicobacter Pylori Eradication in Routine Clinical Practice
Who cites it
20 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Sequential versus standard triple first-line therapy for Helicobacter pylori eradication.The Cochrane database of systematic reviews · 2016Pooled it
- Optimum duration of regimens for Helicobacter pylori eradication.The Cochrane database of systematic reviews · 2013Pooled it
- Global eradication rates for Helicobacter pylori infection: systematic review and meta-analysis of sequential therapy.BMJ (Clinical research ed.) · 2013Pooled it
- The sequential therapy regimen for Helicobacter pylori eradication: a pooled-data analysis.Gut · 2007Pooled it
- Sequential eradication of Helicobacter pylori as a treatment for immune thrombocytopenia in patients with moderate thrombocytopenia: a multicenter prospective randomized phase 3 study.Annals of hematology · 2022Trial
- Helicobacter pylori eradication: sequential therapy and Lactobacillus reuteri supplementation.World journal of gastroenterology · 2012Trial
- 13C-urea breath test values and Helicobacter pylori eradication.Digestive diseases and sciences · 2008Trial
- BeyondMedicina (Kaunas, Lithuania) · 2025Review
- Sequential versus Standard Triple Therapy for First-LineAntibiotics (Basel, Switzerland) · 2024Review
- Article
- Helicobacter pylori: management in 2013.World journal of gastroenterology · 2014Review
- Rational Helicobacter pylori therapy: evidence-based medicine rather than medicine-based evidence.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2014Article
- Gastric Intestinal Metaplasia in an Underserved Population in the USA: Prevalence, Epidemiologic and Clinical Features.Gastroenterology research and practice · 2013Article
- Role of gastritis pattern on Helicobacter pylori eradication.Internal and emergency medicine · 2012Article
- Review
- Follow-up of intestinal metaplasia in the stomach: When, how and why.World journal of gastrointestinal oncology · 2012Article
- Modified Sequential Therapy Regimen versus Conventional Triple Therapy for Helicobacter Pylori Eradication in Duodenal Ulcer Patients in China: A Multicenter Clinical Comparative Study.Gastroenterology research and practice · 2012Article
- Update on non-bismuth quadruple (concomitant) therapy for eradication of Helicobacter pylori.Clinical and experimental gastroenterology · 2012Article
- Sequential Therapy for Helicobacter Pylori Eradication: The Time is Now!Therapeutic advances in gastroenterology · 2009Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHelicobacter pylori eradication rates achieved by standard seven-day triple therapies are decreasing in several countries, while a novel 10-day sequential regimen has achieved a very high success rate. A longer 10-day triple therapy, similar to the sequential regimen, was tested to see whether it could achieve a better infection cure rate.
methodsPatients with nonulcer dyspepsia and H pylori infection were randomly assigned to one of the following three therapies: esomeprazole 20 mg, clarithromycin 500 mg and amoxycillin 1 g for seven days or 10 days, or a 10-day sequential regimen including esomeprazole 20 mg plus amoxycillin 1 g for five days and esomeprazole 20 mg, clarithromycin 500 mg and tinidazole 500 mg for the remaining five days. All drugs were given twice daily. H pylori eradication was checked four to six weeks after treatment by using a 13C-urea breath test.
resultsOverall, 213 patients were enrolled. H pylori eradication was achieved in 75.7% and 77.9%, in 81.7% and 84.1%, and in 94.4% and 97.1% of patients following seven-day or 10-day triple therapy and the 10-day sequential regimen, at intention-to-treat and per protocol analyses, respectively. The eradication rate following the sequential regimen was higher than either seven-day (P=0.002) or 10-day triple therapy (P=0.02), while no significant difference emerged between the latter two regimens (P=0.6).
conclusionsThe 10-day sequential regimen was significantly more effective than both triple regimens, while 10-day triple therapy failed to significantly increase the H pylori eradication rate achieved by the standard seven-day regimen.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.