ReviewJournal of perinatology : official journal of the California Perinatal Association2006
Oxygen and retinopathy of prematurity.
Review in Journal of perinatology : official journal of the California Perinatal Association, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 113 citations in OpenAlex.
- Umbilical cord management in newborn resuscitation: a systematic review and meta-analysis.Pediatric research · 2025Pooled it
- Retinopathy of prematurity: Moving beyond oxygen.Early human development · 2026Review
- Oxygen therapy-related risk factors for aggressive retinopathy of prematurity in low-risk preterm neonates.Pediatric research · 2026Article
- Beyond oxygen targets: the DOSE framework as a conceptual model for dynamic oxygen stewardship in retinopathy of prematurity.Frontiers in pediatrics · 2026Article
- Review
- Neonatal sepsis as a cause of retinopathy of prematurity: An etiological explanation.Progress in retinal and eye research · 2024Review
- Study protocol of OmegaROP-2 prospective study: expression of placental fatty acid receptors in preterm newborns with retinopathy of prematurity.BMC ophthalmology · 2023Article
- Incidence of Retinopathy of Prematurity in Neonates with Neonatal Sepsis.Archives of Iranian medicine · 2023Article
- Oxygen toxicity: cellular mechanisms in normobaric hyperoxia.Cell biology and toxicology · 2023Review
- Association Between Vitamin Deficiencies and Ophthalmological Conditions.Clinical ophthalmology (Auckland, N.Z.) · 2023Review
- The Role of Melatonin in Pregnancy and the Health Benefits for the Newborn.Biomedicines · 2022Review
- Role of Oxidative Stress in Retinal Disease and the Early Intervention Strategies: A Review.Oxidative medicine and cellular longevity · 2022Review
- The Effect of Pasteurization on the Antioxidant Properties of Human Milk: A Literature Review.Antioxidants (Basel, Switzerland) · 2021Review
- T Lymphocytes, Multi-Omic Interactions and Bronchopulmonary Dysplasia.Frontiers in pediatrics · 2021Review
- Single nucleotide vitamin D receptor polymorphisms (FokI, BsmI, ApaI, and TaqI) in the pathogenesis of prematurity complications.Scientific reports · 2020Article
- Turning the Oxygen Dial: Balancing the Highs and Lows.Trends in cell biology · 2020Review
- Trans-pars-planar illumination enables a 200° ultra-wide field pediatric fundus camera for easy examination of the retina.Biomedical optics express · 2020Article
- Effects of Hyperoxia on the Refraction in Murine Neonatal and Adult Models.International journal of molecular sciences · 2019Article
- Incidence and risk factors of retinopathy of prematurity in three neonatal intensive care units in Palestine.BMC ophthalmology · 2019Article
- India to gear up to the challenge of "third epidemic" of retinopathy of prematurity in the world.Indian journal of ophthalmology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Retinopathy of prematurity is on the rise and a third epidemic has been identified. In spite of extensive research and progress in the understanding of this disease in recent years, 50 000 children worldwide are blinded by this condition each year. The relation between hyperoxia, low-gestational age, growth retardation, oxygen dependent growth factors, and oxidative stress are now being understood more clearly. We know that in the first phase of retinopathy of prematurity, hyperoxia inhibits vascular endothelial growth factor. In the second phase, vascular endothelial growth factor rises, and when insulin-like growth factor-1 reaches a threshold around 32 to 34 weeks postconceptional age, uncontrolled neovascularization may occur. It is not known whether this new knowledge will have implications for future therapy. However, by strictly avoiding hyperoxia, that is, SaO2>92-93% and avoiding fluctuations in SaO2, it is possible to control and prevent severe retinopathy of prematurity in most cases.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.