ArticleGenes & development2006
Polycomb group-dependent Cyclin A repression in Drosophila.
Article in Genes & development, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 59 citations in OpenAlex.
- Polycomb Group Proteins inBiology · 2026Review
- EMF2b-1 regulates endosperm cell cycling through PRC2 recruitment in maize.Genome biology · 2026Article
- Epigenetic Regulation in Drosophila Tumor Models.Advances in experimental medicine and biology · 2025Review
- Polycomb Group Protein CBX7 Represses Cardiomyocyte Proliferation Through Modulation of the TARDBP/RBM38 Axis.Circulation · 2023Article
- The Polycomb group protein MEDEA controls cell proliferation and embryonic patterning in Arabidopsis.Developmental cell · 2021Article
- A theoretical model of Polycomb/Trithorax action unites stable epigenetic memory and dynamic regulation.Nature communications · 2020Article
- Single-cell absolute contact probability detection reveals chromosomes are organized by multiple low-frequency yet specific interactions.Nature communications · 2017Article
- Repression of Abd-B by Polycomb is critical for cell identity maintenance in adult Drosophila testis.Scientific reports · 2017Article
- Article
- A fine balance: epigenetic control of cellular quiescence by the tumor suppressor PRDM2/RIZ at a bivalent domain in the cyclin a gene.Nucleic acids research · 2015Article
- Visualizing genomes with Oligopaint FISH probes.Current protocols in molecular biology · 2014Article
- Polycomb protein SCML2 regulates the cell cycle by binding and modulating CDK/CYCLIN/p21 complexes.PLoS biology · 2013Article
- Polycomb silencing of the Drosophila 4E-BP gene regulates imaginal disc cell growth.Developmental biology · 2013Article
- In vivo regulation of E2F1 by Polycomb group genes in Drosophila.G3 (Bethesda, Md.) · 2012Article
- Tunicate cytostatic factor TC14-3 induces a polycomb group gene and histone modification through Ca(2+) binding and protein dimerization.BMC cell biology · 2012Article
- Polycomb group genes Psc and Su(z)2 maintain somatic stem cell identity and activity in Drosophila.PloS one · 2012Article
- Developmental regulation of CYCA2s contributes to tissue-specific proliferation in Arabidopsis.The EMBO journal · 2011Article
- Quantitative analysis of polycomb response elements (PREs) at identical genomic locations distinguishes contributions of PRE sequence and genomic environment.Epigenetics & chromatin · 2011Article
- Polycomb preferentially targets stalled promoters of coding and noncoding transcripts.Genome research · 2011Article
- A tumor suppressor activity of Drosophila Polycomb genes mediated by JAK-STAT signaling.Nature genetics · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polycomb group (PcG) and trithorax group (trxG) proteins are well known for their role in the maintenance of silent and active expression states of homeotic genes. However, PcG proteins may also be required for the control of cellular proliferation in vertebrates. In Drosophila, PcG factors act by associating with specific DNA regions termed PcG response elements (PREs). Here, we have investigated whether Drosophila cell cycle genes are directly regulated by PcG proteins through PREs. We have isolated a PRE that regulates Cyclin A (CycA) expression. This sequence is bound by the Polycomb (PC) and Polyhomeotic (PH) proteins of the PcG, and also by GAGA factor (GAF), a trxG protein that is usually found associated with PREs. This sequence causes PcG- and trxG-dependent variegation of the mini-white reporter gene in transgenic flies. The combination of FISH with PC immunostaining in embryonic cells shows that the endogenous CycA gene colocalizes with PC at foci of high PC concentration named PcG bodies. Finally, loss of function of the Pc gene and overexpression of Pc and ph trigger up-regulation and down-regulation, respectively, of CycA expression in embryos. These results demonstrate that CycA is directly regulated by PcG proteins, linking them to cell cycle control in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.