ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Serotonergic enhancement of a 4-AP-sensitive current mediates the synaptic depression phase of spike timing-dependent neuromodulation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 24 citations in OpenAlex.
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- The transient potassium outward current has different roles in modulating the pyloric and gastric mill rhythms in the stomatogastric ganglion.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2017Article
- Phylogenetic and individual variation in gastropod central pattern generators.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2015Review
- Neuromodulation of neurons and synapses.Current opinion in neurobiology · 2014Review
- Neuromodulation as a mechanism for the induction of repetition priming.Current opinion in neurobiology · 2014Review
- The past, present, and future of real-time control in cellular electrophysiology.IEEE transactions on bio-medical engineering · 2014Review
- Parallel evolution of serotonergic neuromodulation underlies independent evolution of rhythmic motor behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Peptide neuromodulation of synaptic dynamics in an oscillatory network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Context-dependent modulation of auditory processing by serotonin.Hearing research · 2011Review
- State-, timing-, and pattern-dependent neuromodulation of synaptic strength by a serotonergic interneuron.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- An input-representing interneuron regulates spike timing and thereby phase switching in a motor network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Altering cAMP levels within a central pattern generator modifies or disrupts rhythmic motor output.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2007Article
- Long-term sensitization training produces spike narrowing in Aplysia sensory neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
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4 authors at 2 institutions in 1 country.
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Abstract
The mechanism underlying spike timing-dependent neuromodulation (STDN) was investigated in the opisthobranch mollusc Tritonia diomedea. The serotonergic dorsal swim interneurons (DSIs) dynamically modulated the synaptic output of ventral swim interneuron B (VSI); immediately after DSI stimulation, there was a potentiation of VSI synaptic strength followed by a longer-lasting synaptic depression. The potentiation phase of STDN was unaffected by spike broadening produced by the potassium channel blocker 4-aminopyridine (4-AP). In contrast, the depression phase was eliminated by 4-AP. Bath-applied serotonin (5-HT) decreased VSI spike duration and increased the magnitude of the A-current (IA), a voltage-dependent, transient, outward current. 4-AP preferentially blocked IA and prevented the spike narrowing caused by 5-HT, uncovering the full extent of 5-HT-induced synaptic potentiation. A consistent correlation was observed between IA and spike duration, but the correlation between synaptic strength and spike duration differed between preparations. Conductance-based simulations showed that the magnitude of A-current conductance could affect spike duration and gave an estimation of the change needed to produce spike narrowing. An artificial IA introduced into the VSI in the presence of 4-AP by means of the dynamic-clamp technique restored spike duration and gave a further approximation of the magnitude of modulation needed for spike narrowing. Together, these results suggest a mechanism for STDN: the DSIs release 5-HT, which causes a spike duration-independent enhancement of synaptic strength and a longer-lasting enhancement of IA that narrows the VSI spike and hence decreases VSI synaptic strength. Thus, STDN arises from the dynamics of independent intracellular signaling events.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.