ArticleMolecular biology of the cell2006
Ran is required before metaphase for spindle assembly and chromosome alignment and after metaphase for chromosome segregation and spindle midbody organization.
Article in Molecular biology of the cell, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 45 citations in OpenAlex.
- Proteins involved in cell division have broad developmental functions.Developmental biology · 2025Article
- Motorless transport of microtubules along tubulin, RanGTP, and salt gradients.Nature communications · 2024Article
- Ran GTPase and Its Importance in Cellular Signaling and Malignant Phenotype.International journal of molecular sciences · 2023Review
- Ran-GTP/-GDP-dependent nuclear accumulation of NONEXPRESSOR OF PATHOGENESIS-RELATED GENES1 and TGACG-BINDING FACTOR2 controls salicylic acid-induced leaf senescence.Plant physiology · 2022Article
- The association ofJournal of Cancer · 2020Article
- The nucleoporin ALADIN regulates Aurora A localization to ensure robust mitotic spindle formation.Molecular biology of the cell · 2015Article
- Review
- Ran signaling in melanoma: implications for the development of alternative therapeutic strategies.Cancer letters · 2015Article
- The Ran Pathway in Drosophila melanogaster Mitosis.Frontiers in cell and developmental biology · 2015Review
- GTPase Ran strongly accumulates at the kinetochores of somatic chromosomes in the spermatogonial mitoses of Acricotopus lucidus (Diptera, Chironomidae).Protoplasma · 2014Article
- Chromatin-mediated microtubule nucleation in Drosophila syncytial embryos.Communicative & integrative biology · 2014Article
- New mitotic regulators released from chromatin.Frontiers in oncology · 2013Review
- In vivo FRET imaging revealed a regulatory role of RanGTP in kinetochore-microtubule attachments via Aurora B kinase.PloS one · 2012Article
- Specific Cooperation Between Imp-α2 and Imp-β/Ketel in Spindle Assembly During Drosophila Early Nuclear Divisions.G3 (Bethesda, Md.) · 2012Article
- RanGTP is required for meiotic spindle organization and the initiation of embryonic development in Drosophila.Journal of cell science · 2011Article
- A Nup133-dependent NPC-anchored network tethers centrosomes to the nuclear envelope in prophase.The Journal of cell biology · 2011Article
- Dynamic distribution of nuclear coactivator 4 during mitosis: association with mitotic apparatus and midbodies.PloS one · 2011Article
- Kinesin-5-dependent poleward flux and spindle length control in Drosophila embryo mitosis.Molecular biology of the cell · 2009Article
- Regulation of chromatin binding by a conformational switch in the tail of the Ran exchange factor RCC1.The Journal of cell biology · 2008Article
- Anillin-mediated targeting of peanut to pseudocleavage furrows is regulated by the GTPase Ran.Molecular biology of the cell · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Ran pathway has been shown to have a role in spindle assembly. However, the extent of the role of the Ran pathway in mitosis in vivo is unclear. We report that perturbation of the Ran pathway disrupted multiple steps of mitosis in syncytial Drosophila embryos and uncovered new mitotic processes that are regulated by Ran. During the onset of mitosis, the Ran pathway is required for the production, organization, and targeting of centrosomally nucleated microtubules to chromosomes. However, the role of Ran is not restricted to microtubule organization, because Ran is also required for the alignment of chromosomes at the metaphase plate. In addition, the Ran pathway is required for postmetaphase events, including chromosome segregation and the assembly of the microtubule midbody. The Ran pathway mediates these mitotic events, in part, by facilitating the correct targeting of the kinase Aurora A and the kinesins KLP61F and KLP3A to spindles.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.