ArticleMicrobial cell factories2006
Expression of the heat shock gene clpL of Streptococcus thermophilus is induced by both heat and cold shock.
Article in Microbial cell factories, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 35 citations in OpenAlex.
- Unravelling the key factors for the dominance of Leuconostoc starters during kimchi fermentation.NPJ science of food · 2025Article
- Understanding the Probiotic Bacterial Responses Against Various Stresses in Food Matrix and Gastrointestinal Tract: A Review.Probiotics and antimicrobial proteins · 2023Review
- Significance of Individual Domains of ClpL: A Novel Chaperone fromBiochemistry · 2020Article
- Adaptation of Lactobacillus plantarum to Ampicillin Involves Mechanisms That Maintain Protein Homeostasis.mSystems · 2020Article
- Comparative Analysis ofToxins · 2019Article
- The Phenotypic Analysis ofFrontiers in microbiology · 2019Article
- Transcriptome and Proteome of Fish-PathogenicFrontiers in microbiology · 2018Article
- Stress Physiology of Lactic Acid Bacteria.Microbiology and molecular biology reviews : MMBR · 2016Review
- CtsR regulation in mcsAB-deficient Gram-positive bacteria.Journal of bacteriology · 2012Article
- The rgg0182 gene encodes a transcriptional regulator required for the full Streptococcus thermophilus LMG18311 thermal adaptation.BMC microbiology · 2011Article
- Transcriptome analysis of adaptive heat shock response of Streptococcus thermophilus.PloS one · 2011Article
- Two homologous Agr-like quorum-sensing systems cooperatively control adherence, cell morphology, and cell viability properties in Lactobacillus plantarum WCFS1.Journal of bacteriology · 2008Article
- Improvement of raw sausage fermentation by stress-conditioning of the starter organism Lactobacillus sakei.Current microbiology · 2008Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHeat and cold shock response are normally considered as independent phenomena. A small amount of evidence suggests instead that interactions may exist between them in two Lactococcus strains.
resultsWe show the occurrence of molecular relationships between the mechanisms of cold and heat adaptations in Streptococcus thermophilus, a lactic acid bacterium widely used in dairy fermentation, where it undergoes both types of stress. We observed that cryotolerance is increased when cells are pre-incubated at high temperature. In addition, the production of a protein, identified as ClpL, a member of the heat-shock ATPase family Clp A/B, is induced at both high and low temperature. A knock-out clpL mutant is deficient in both heat and cold tolerance. However lack of production of this protein does not abolish the positive effect of heat pre-treatment towards cryotolerance.
conclusionDual induction of ClpL by cold and heat exposure of cells and reduced tolerance to both temperature shocks in a clpL mutant indicates that the two stress responses are correlated in S. thermophilus. However this protein is not responsible by itself for cryotolerance of cells pre-treated at high temperature, indicating that ClpL is necessary for the two phenomena, but does not account by itself for the relationships between them.
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