ArticleMolecular and cellular biochemistry2006
All-trans retinoic acid induces free radical generation and modulate antioxidant enzyme activities in rat sertoli cells.
Article in Molecular and cellular biochemistry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 51 citations in OpenAlex.
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- The Beneficial Effect of Proanthocyanidins and Icariin on Biochemical Markers of Bone Turnover in Rats.International journal of molecular sciences · 2018Article
- Chronic Intermittent Hypoxia Causes Lipid Peroxidation and Altered Phase 1 Drug Metabolizing Enzymes in the Neonatal Rat Liver.Reactive oxygen species (Apex, N.C.) · 2017Article
- Biodegradable Elastomers with Antioxidant and Retinoid-like Properties.ACS biomaterials science & engineering · 2016Article
- Association study between novel CYP26 polymorphisms and the risk of betel quid-related malignant oral disorders.TheScientificWorldJournal · 2015Article
- Expression of a splice variant of CYP26B1 in betel quid-related oral cancer.TheScientificWorldJournal · 2014Article
- In vitro optimization of retinoic acid-induced neuritogenesis and TH endogenous expression in human SH-SY5Y neuroblastoma cells by the antioxidant Trolox.Molecular and cellular biochemistry · 2011Article
- Retinoic acid stimulation of VEGF secretion from human endometrial stromal cells is mediated by production of reactive oxygen species.The Journal of physiology · 2011Article
- Retinoic acid is a cofactor for translational regulation of vascular endothelial growth factor in human endometrial stromal cells.Molecular endocrinology (Baltimore, Md.) · 2010Article
- Increased receptor for advanced glycation endproducts immunocontent in the cerebral cortex of vitamin A-treated rats.Neurochemical research · 2009Article
- Effects of retinoic acid isomers on apoptosis and enzymatic antioxidant system in human breast cancer cells.Nutrition research and practice · 2009Article
- Retinoic acid regulates the human methionine sulfoxide reductase A (MSRA) gene via two distinct promoters.Genomics · 2009Article
- Antioxidant systems and oxidative stress in the testes.Oxidative medicine and cellular longevityReview
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Authors and funding
7 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
In this work we investigated the effects of retinoic acid (RA) in Sertoli cells. Sertoli cells isolated from 15-day-old Wistar rats were previously cultured for 48 h and then treated with RA for 24 h. RA at high doses (1-10 microM) increased TBARS levels and induced a decrease in cell viability. At low doses (0.1-100 nM) RA did not increase TBARS level. RA also did not increase cell death at these doses. In order to investigate changes in antioxidant defenses we measured the CAT, SOD and GPx activities in Sertoli cells treated with RA. Compared to control, RA increased around 200% SOD activity in all doses tested (0.1-100 nM); GPx activity was increased 407.49, 208.98 and 243.88% (0.1, 1 and 10 nM, respectively); CAT activity was increased 127% with RA 1 nM. To clarify if RA induces ROS production per se, we performed experiments in vitro using 2-deoxyribose as specific substrate of oxidative degradation by *OH radical as well as TRAP assay. RA at 10 microM increased 2-deoxyribose degradation, suggesting that some of the RA-induced effects are mediated via *OH formation. Furthermore, the total reactive antioxidant potential (TRAP) of the RA was determined. At low concentrations RA has induced no redox activity. Conversely, higher concentration of RA (1-10 microM) increased chemiluminescence. The chemiluminescence produced was directly proportional to radical generation. We provide, for the first time, evidence for a free radical generation by RA. Our results demonstrated that RA plays an important role in Sertoli cells and these effects appear to be mediated by ROS.
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