ArticleCell cycle (Georgetown, Tex.)2006
The GOD of hematopoietic stem cells: a clonal diversity model of the stem cell compartment.
Article in Cell cycle (Georgetown, Tex.), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- New insights into hematopoietic differentiation landscapes from single-cell RNA sequencing.Blood · 2019Review
- Functional Integrity and Gene Expression Profiles of Human Cord Blood-Derived Hematopoietic Stem and Progenitor Cells Generated In Vitro.Stem cells translational medicine · 2018Article
- The regulation of hematopoietic stem cell populations.F1000Research · 2016Review
- Review
- Article
- Lifespan differences in hematopoietic stem cells are due to imperfect repair and unstable mean-reversion.PLoS computational biology · 2013Article
- Review
- Stem cell aging: survival of the laziest?Cell cycle (Georgetown, Tex.) · 2008Review
- Expansion of human hematopoietic stem cells for transplantation: trends and perspectives.Cytotechnology · 2008Article
- Stem cells on patrol.Cell · 2007Article
- Article
- Near-maximal expansions of hematopoietic stem cells in culture using NUP98-HOX fusions.Experimental hematology · 2007Article
- Hematopoietic stem cells: the paradigmatic tissue-specific stem cell.The American journal of pathology · 2006Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Hematopoietic stem cells (HSC) show heterogeneous behavior even when isolated as phenotypically homogeneous populations. The cellular and molecular mechanisms that control the generation of diversity (GOD) in the HSC compartment are not well understood, but have been the focus of much debate. There is increasing evidence that the most important HSC functions, self-renewal and differentiation, are epigenetically preprogrammed and therefore predictable. Indeed, recent data show that the adult HSC compartment consists of a limited number of functionally distinct subsets of HSC. This contradicts older models of HSC behavior, which postulated a single type of HSC that can be continuously molded into different subtypes of HSC. We propose a clonal diversity model where the adult HSC compartment consists of a fixed number of different types of HSC, each with epigenetically preprogrammed behavior. Aging or disease may change the overall function of the HSC population. The model predicts that these changes reflect the relative composition of the HSC subsets, rather than changes in individual HSC. This view has implications for using HSC in experimental and clinical settings. Selection for the appropriate subsets of HSC, rather than attempts to force HSC to adjust, should improve their utility in transplantation and gene transfer applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.