ArticleMolecular and cellular biology2006
Autoregulation of ribosome biosynthesis by a translational response in fission yeast.
Article in Molecular and cellular biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Ageing-associated long non-coding RNA extends lifespan and reduces translation in non-dividing cells.EMBO reports · 2024Article
- Methylation of yeast ribosomal protein S2 is elevated during stationary phase growth conditions.Biochemical and biophysical research communications · 2014Article
- Silencing of the nuclear RPS10 gene encoding mitochondrial ribosomal protein alters translation in arabidopsis mitochondria.The Plant cell · 2013Article
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- Article
- Negative regulation of meiotic gene expression by the nuclear poly(a)-binding protein in fission yeast.The Journal of biological chemistry · 2010Article
- Methylation of ribosomal protein S10 by protein-arginine methyltransferase 5 regulates ribosome biogenesis.The Journal of biological chemistry · 2010Article
- Rmt1 catalyzes zinc-finger independent arginine methylation of ribosomal protein Rps2 in Saccharomyces cerevisiae.Biochemical and biophysical research communications · 2010Article
- Transcript profiling provides evidence of functional divergence and expression networks among ribosomal protein gene paralogs in Brassica napus.The Plant cell · 2009Article
- A methyltransferase-independent function for Rmt3 in ribosomal subunit homeostasis.The Journal of biological chemistry · 2009Article
- Nuclear export competence of pre-40S subunits in fission yeast requires the ribosomal protein Rps2.Nucleic acids research · 2008Article
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- Article
- Protein arginine methyltransferases: from unicellular eukaryotes to humans.Eukaryotic cell · 2007Review
- A network of multiple regulatory layers shapes gene expression in fission yeast.Molecular cell · 2007Article
- Comparative proteomic and transcriptomic profiling of the fission yeast Schizosaccharomyces pombe.Molecular systems biology · 2007Article
- Common gene expression strategies revealed by genome-wide analysis in yeast.Genome biology · 2007Article
- Simplified primer design for PCR-based gene targeting and microarray primer database: two web tools for fission yeast.Yeast (Chichester, England) · 2006Article
- RpL22e, but not RpL22e-like-PA, is SUMOylated and localizes to the nucleoplasm of Drosophila meiotic spermatocytes.Nucleus (Austin, Tex.)Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Maintaining the appropriate balance between the small and large ribosomal subunits is critical for translation and cell growth. We previously identified the 40S ribosomal protein S2 (rpS2) as a substrate of the protein arginine methyltransferase 3 (RMT3) and reported a misregulation of the 40S/60S ratio in rmt3 deletion mutants of Schizosaccharomyces pombe. For this study, using DNA microarrays, we have investigated the genome-wide biological response of rmt3-null cells to this ribosomal subunit imbalance. Whereas little change was observed at the transcriptional level, a number of genes showed significant alterations in their polysomal-to-monosomal ratios in rmt3Delta mutants. Importantly, nearly all of the 40S ribosomal protein-encoding mRNAs showed increased ribosome density in rmt3 disruptants. Sucrose gradient analysis also revealed that the ribosomal subunit imbalance detected in rmt3-null cells is due to a deficit in small-subunit levels and can be rescued by rpS2 overexpression. Our results indicate that rmt3-null fission yeast compensate for the reduced levels of small ribosomal subunits by increasing the ribosome density, and likely the translation efficiency, of 40S ribosomal protein-encoding mRNAs. Our findings support the existence of autoregulatory mechanisms that control ribosome biosynthesis and translation as an important layer of gene regulation.
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