ArticleMolecular and cellular biology2006
A role for gcn5-mediated global histone acetylation in transcriptional regulation.
Article in Molecular and cellular biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 47 citations in OpenAlex.
- Ubiquitin proteasome system (UPS): a crucial determinant of the epigenetic landscape in cancer.Epigenomics · 2025Review
- Functional tug of war between kinases, phosphatases, and the Gcn5 acetyltransferase in chromatin and cell cycle checkpoint controls.G3 (Bethesda, Md.) · 2023Article
- Global Microbiota-Dependent Histone Acetylation Patterns Are Irreversible and Independent of Short Chain Fatty Acids.Hepatology (Baltimore, Md.) · 2021Article
- Silencing of Unintegrated Retroviral DNAs.Viruses · 2021Review
- GCN5 acetylation is required for craniofacial chondrocyte maturation.Developmental biology · 2020Article
- Histone acetyltransferase GCN5-mediated regulation of long non-coding RNA At4 contributes to phosphate starvation response in Arabidopsis.Journal of experimental botany · 2019Article
- GCN5 modulates trichome initiation in Arabidopsis by manipulating histone acetylation of core trichome initiation regulator genes.Plant cell reports · 2019Article
- The Elongator subunit Elp3 is a non-canonical tRNA acetyltransferase.Nature communications · 2019Article
- Article
- Mortality factor 4 like 1 protein mediates epithelial cell death in a mouse model of pneumonia.Science translational medicine · 2015Article
- GENERAL CONTROL NONREPRESSED PROTEIN5-Mediated Histone Acetylation of FERRIC REDUCTASE DEFECTIVE3 Contributes to Iron Homeostasis in Arabidopsis.Plant physiology · 2015Article
- Uncoupling histone turnover from transcription-associated histone H3 modifications.Nucleic acids research · 2015Article
- Regulation of histone modifying enzymes by the ubiquitin-proteasome system.Biochimica et biophysica acta · 2014Review
- Independent RNA polymerase II preinitiation complex dynamics and nucleosome turnover at promoter sites in vivo.Genome research · 2014Article
- Mediator is an intrinsic component of the basal RNA polymerase II machinery in vivo.Nucleic acids research · 2013Article
- Responses of the embryonic epigenome to maternal diabetes.Birth defects research. Part A, Clinical and molecular teratology · 2012Article
- N-Myc and GCN5 regulate significantly overlapping transcriptional programs in neural stem cells.PloS one · 2012Article
- Linking yeast Gcn5p catalytic function and gene regulation using a quantitative, graded dominant mutant approach.PloS one · 2012Article
- Bacteria-induced natural product formation in the fungus Aspergillus nidulans requires Saga/Ada-mediated histone acetylation.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Antagonistic Gcn5-Hda1 interactions revealed by mutations to the Anaphase Promoting Complex in yeast.Cell division · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcriptional activators often require histone acetyltransferases (HATs) for full activity. The common explanation is that activators directly recruit HATs to gene promoters to locally hyperacetylate histones and thereby facilitate transcription complex formation. However, in addition to being targeted to specific loci, HATs such as Gcn5 also modify histones genome-wide. Here we provide evidence for a role of this global HAT activity in regulated transcription. We show that activation by direct recruitment of the transcriptional machinery neither recruits Gcn5 nor induces changes in histone acetylation yet can strongly depend on Gcn5 at promoters showing a high basal state of Gcn5-mediated histone acetylation. We also show that Gcn5 dependency varies among core promoters and is influenced by the strength of interaction used to recruit the machinery and by the affinity of the latter for the core promoter. These data support a role for global Gcn5 HAT activity in modulating transcription independently of its known coactivator function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.