ArticleAmerican journal of physiology. Renal physiology2006
Transport of estrone sulfate by the novel organic anion transporter Oat6 (Slc22a20).
Article in American journal of physiology. Renal physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 46 citations in OpenAlex.
- Illuminating the function of the orphan transporter, SLC22A10, in humans and other primates.Nature communications · 2024Article
- Solute transporters and malignancy: establishing the role of uptake transporters in breast cancer and breast cancer metastasis.Cancer metastasis reviews · 2020Review
- The SLC22 Transporter Family: A Paradigm for the Impact of Drug Transporters on Metabolic Pathways, Signaling, and Disease.Annual review of pharmacology and toxicology · 2018Review
- Trafficking and other regulatory mechanisms for organic anion transporting polypeptides and organic anion transporters that modulate cellular drug and xenobiotic influx and that are dysregulated in disease.British journal of pharmacology · 2017Review
- Vaginal ecosystem modeling of growth patterns of anaerobic bacteria in microaerophilic conditions.Anaerobe · 2017Article
- Multikinase Inhibitors Induce Cutaneous Toxicity through OAT6-Mediated Uptake and MAP3K7-Driven Cell Death.Cancer research · 2016Article
- Shared Ligands Between Organic Anion Transporters (OAT1 and OAT6) and Odorant Receptors.Drug metabolism and disposition: the biological fate of chemicals · 2015Article
- The organic anion transporter (OAT) family: a systems biology perspective.Physiological reviews · 2015Review
- Article
- What do drug transporters really do?Nature reviews. Drug discovery · 2015Review
- Variation of urate transport in the nephrons in subtypes of hyperuricemia.Nephron extra · 2013Article
- Mutational analysis of the role of GXXXG motif in the function of human organic anion transporter 1 (hOAT1).International journal of biochemistry and molecular biology · 2011Article
- The Role of Dileucine in the Expression and Function of Human Organic Anion Transporter 1 (hOAT1).International journal of biochemistry and molecular biology · 2011Article
- Organic anion transporter 6 (Slc22a20) specificity and Sertoli cell-specific expression provide new insight on potential endogenous roles.The Journal of pharmacology and experimental therapeutics · 2010Article
- Xenobiotic, bile acid, and cholesterol transporters: function and regulation.Pharmacological reviews · 2010Review
- Angiotensin II inhibits activity of human organic anion transporter 3 through activation of protein kinase Calpha: accelerating endocytosis of the transporter.European journal of pharmacology · 2010Article
- Putative transmembrane domain 12 of the human organic anion transporter hOAT1 determines transporter stability and maturation efficiency.The Journal of pharmacology and experimental therapeutics · 2010Article
- Short-term regulation of organic anion transporters.Pharmacology & therapeutics · 2010Review
- Comparison of rat olfactory mucosal responses to carcinogenic and non-carcinogenic chloracetanilides.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2009Article
- Physiology, structure, and regulation of the cloned organic anion transporters.Xenobiotica; the fate of foreign compounds in biological systems · 2008Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Recently, a novel Slc22 gene family member expressed in murine olfactory mucosa was identified and based on sequence homology proposed to be an organic anion transporter [Oat6 (Slc22a20); J. C. Monte, M. A. Nagle, S. A. Eraly, and S. K. Nigam. Biochem Biophys Res Commun 323: 429-436, 2004]. However, no functional data for Oat6 was reported. In the present study, we demonstrate that murine Oat6 mediates the inhibitable transport of estrone sulfate using both Xenopus oocyte expression assay and Chinese hamster ovary (CHO) cells stably transfected with mOat6 (CHO-mOat6). Uptake was virtually eliminated by probenecid and the anionic herbicide 2,4-dichlorophenoxyacetate. The organic anions ochratoxin A, salicylate, penicillin G, p-aminohippurate, and urate inhibited mOat6-mediated accumulation to varying degrees. Transport of estrone sulfate by mOat6 was demonstrated to be saturable, and K(m) estimates of 109.8 +/- 22.6 microM in oocytes and 44.8 +/- 7.3 microM in CHO-mOat6 cells were obtained. Inhibitory constants for 2,4-dichlorophenoxyacetate (15.7 +/- 2.0 microM), salicylate (49.0 +/- 4.4 microM), probenecid (8.3 +/- 2.5 microM), and penicillin G (1,450 +/- 480 microM) were also determined. Accumulation of estrone sulfate mediated by mOat6 was significantly trans-stimulated by glutarate, indicating that mOat6 functions as an organic anion/dicarboxylate exchanger. These data demonstrate for the first time that the novel murine gene Oat6 (Slc22a20) encodes a functional organic anion transporter and mOat6 is indeed the newest member of the OAT gene family.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.