ArticleNucleic acids research2006
Diels-Alder cycloadditions in water for the straightforward preparation of peptide-oligonucleotide conjugates.
Article in Nucleic acids research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 74 citations in OpenAlex.
- Peptide-Oligonucleotide Conjugation: Chemistry and Therapeutic Applications.Current issues in molecular biology · 2024Review
- BRET-based biosensors for SARS-CoV-2 oligonucleotide detection.Frontiers in bioengineering and biotechnology · 2024Article
- Special Issue "Frontiers in Nucleic Acid Chemistry-In Memory of Professor Enrique Pedroso for His Outstanding Contributions to Nucleic Acid Chemistry".Molecules (Basel, Switzerland) · 2023Article
- Lipid and Peptide-Oligonucleotide Conjugates for Therapeutic Purposes: From Simple Hybrids to Complex Multifunctional Assemblies.Pharmaceutics · 2023Review
- Chemistry of Peptide-Oligonucleotide Conjugates: A Review.Molecules (Basel, Switzerland) · 2021Review
- Harnessing molecular recognition for localized drug delivery.Advanced drug delivery reviews · 2021Review
- Smart hybrid materials by conjugation of responsive polymers to biomacromolecules.Nature materials · 2015Review
- Quantitative structure-activation barrier relationship modeling for Diels-Alder ligations utilizing quantum chemical structural descriptors.Chemistry Central journal · 2013Article
- An activated triple bond linker enables 'click' attachment of peptides to oligonucleotides on solid support.Nucleic acids research · 2011Article
- Growing applications of "click chemistry" for bioconjugation in contemporary biomedical research.Cancer biotherapy & radiopharmaceuticals · 2009Review
- Diene-modified nucleotides for the Diels-Alder-mediated functional tagging of DNA.Nucleic acids research · 2009Article
- A versatile method for the preparation of conjugates of peptides with DNA/PNA/analog by employing chemo-selective click reaction in water.Nucleic acids research · 2007Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Diels-Alder reaction between diene-modified oligonucleotides and maleimide-derivatized peptides afforded peptide-oligonucleotide conjugates with high purity and yield. Synthesis of the reagents was easily accomplished by on-column derivatization of the corresponding peptides and oligonucleotides. The cycloaddition reaction was carried out in mild conditions, in aqueous solution at 37 degrees C. The speed of the reaction was found to vary depending on the size of the reagents, but it can be completed in 8-10 h by reacting the diene-oligonucleotide with a small excess of maleimide-peptide.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.