Trial reportClinical autonomic research : official journal of the Clinical Autonomic Research Society2006
Subtle involvement of the parasympathetic nervous system in patients with irritable bowel syndrome.
Trial report in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02874495 (Anticipation Effect on Painful Phenomenons Linked to Rectal Distension for Patients With a Crohn's Disease in Remission), which is not on this map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Anticipation Effect on Painful Phenomenons Linked to Rectal Distension for Patients With a Crohn's Disease in Remission: Functional MRI Study
Who cites it
14 citing papers in PubMed, 45 citations in OpenAlex.
- Can the change of vasomotor activity in irritable bowel syndrome patients be detectedWorld journal of radiology · 2023Article
- Interoceptive Abilities in Inflammatory Bowel Diseases and Irritable Bowel Syndrome.Frontiers in psychiatry · 2020Article
- Association between vasomotor rhinitis and irritable bowel syndrome.Allergy & rhinology (Providence, R.I.) · 2016Article
- Mast Cell-dependent Mesenteric Afferent Activation by Mucosal Supernatant From Different Bowel Segments of Guinea Pigs With Post-infectious Irritable Bowel Syndrome.Journal of neurogastroenterology and motility · 2015Article
- Nicotine enhances inhibition of mouse vagal motor neurons by modulating excitability of premotor GABAergic neurons in the nucleus tractus solitarii.Journal of neurophysiology · 2015Article
- Convergence of neuro-endocrine-immune pathways in the pathophysiology of irritable bowel syndrome.World journal of gastroenterology · 2014Review
- Irritable bowel syndrome: the role of food in pathogenesis and management.Gastroenterology & hepatology · 2014Article
- Autonomic response to a visceral stressor is dysregulated in irritable bowel syndrome and correlates with duration of disease.Neurogastroenterology and motility · 2013Article
- Responsiveness to nicotine of neurons of the caudal nucleus of the solitary tract correlates with the neuronal projection target.Journal of neurophysiology · 2012Article
- Effect of hot-attribute aged ginger tea on chinese medical pulse condition of healthy young humans.Journal of traditional and complementary medicine · 2011Article
- Relationships between Irritable Bowel Syndrome Pain, Skin Temperature Indices of Autonomic Dysregulation, and Sensitivity to Thermal Cutaneous Stimulation.Pain research and treatment · 2010Article
- Autonomic function at rest and in response to emotional and rectal stimuli in women with irritable bowel syndrome.Digestive diseases and sciences · 2008Article
- The effect of intraduodenal glucose on muscle sympathetic nerve activity in healthy young and older subjects.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2008Article
- Functional findings in irritable bowel syndrome.World journal of gastroenterology · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study comprises assessment of autonomic function in irritable bowel syndrome (IBS) patients, focusing on meal-related changes. In 18 IBS patients (4 males, mean age 45+/-3.0 [SEM] years) and 19 healthy volunteers (6 males, mean age 41+/-3.5 years) blood pressure, heart rate, heart rate variability and muscle sympathetic nerve activity (MSNA) were assessed before, during and after consumption of a standardized meal. In pre- and postprandial phase Valsalva maneuver, cold pressor test (CPT) and deep breathing test were carried out and Visual Analog Scale (VAS) scores for nausea, bloating and pain were obtained. In the IBS group, the meal induced significantly higher VAS scores for pain (P=0.002) and bloating (P=0.02). During food intake, the increase in blood pressure, heart rate and MSNA was equal in patients and controls, but the increase of LF/HF ratio of heart rate variability was significantly higher in the IBS group (median [quartiles] 2.29 [1.14-3.00] versus 0.77 [0.25-1.81]; P=0.03). IBS patients scored lower on pre- and postprandial RRmax/RRmin ratio during deep breathing (DB ratio, P=0.03). The increase in MSNA (burst frequency) in response to CPT tended to be higher in the IBS patients (P=0.07). We conclude that reactivity to food intake, measured as muscle sympathetic nerve activity, is normal in IBS patients. The lower DB ratio and higher LF/HF ratio during food intake in IBS patients is an indication of a reduced parasympathetic reactivity. These results suggest that reduced baseline activity as well as responsiveness of the parasympathetic system could play a role in the pathogenesis of IBS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.