ArticleIntensive care medicine2006
Mean glucose level is not an independent risk factor for mortality in mixed ICU patients.
Article in Intensive care medicine, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- The effect of diabetes on mortality in critically ill patients: a systematic review and meta-analysis.Critical care (London, England) · 2011Pooled it
- Towards a feasible algorithm for tight glycaemic control in critically ill patients: a systematic review of the literature.Critical care (London, England) · 2006Pooled it
- Strict glycaemic control in patients hospitalised in a mixed medical and surgical intensive care unit: a randomised clinical trial.Critical care (London, England) · 2008Trial
- Increasing blood glucose variability is a precursor of sepsis and mortality in burned patients.PloS one · 2012Article
- The metrics of glycaemic control in critical care.Intensive care medicine · 2011Article
- Organ dysfunction is associated with hyperglycemia in critically ill children.Intensive care medicine · 2010Article
- Insulin-treated diabetes is not associated with increased mortality in critically ill patients.Critical care (London, England) · 2010Article
- Hyperglycemia-related mortality in critically ill patients varies with admission diagnosis.Critical care medicine · 2009Article
- Glucose dysmetabolism and prognosis in critical illness.Internal and emergency medicine · 2009Review
- Year in review in Intensive Care Medicine, 2006. I. Experimental studies. Clinical studies: brain injury, renal failure and endocrinology.Intensive care medicine · 2007Review
- Comment on "Mean glucose level is not an independent risk factor for mortality in mixed ICU patients" by Ligtenberg et al.Intensive care medicine · 2006Article
- Accuracy and feasibility of point-of-care and continuous blood glucose analysis in critically ill ICU patients.Critical care (London, England) · 2006Article
- Hyperglycaemia in critically ill patients: marker or mediator of mortality?Critical care (London, England) · 2006Review
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo find out if there is an association between hyperglycaemia and mortality in mixed ICU patients. DESIGN AND
settingRetrospective cohort study over a 2-year period at the medical ICU of a university hospital. MEASUREMENTS: Admission glucose, maximum and mean glucose, length of stay, mortality, insulin therapy and Apache-II score.
resultsIn 1085 consecutive patients, ICU- and hospital mortality were 20 and 25%, respectively. The total number of blood glucose measurements was 10.012. Admission glucose was 7.9 +/- 4.5 mmol/l (mean +/- SD), mean glucose 7.5 +/- 2.9 and maximum glucose 10.0 +/- 5.4 mmol/l. Median ICU length of stay (LOS) was 3.0 days (range 2.0-6.0 days, IQR), and hospital LOS was 16 days (range 7-32 days). In 28% of patients insulin treatment was started. Median Apache-II score was 13. 68% of patients were mechanically ventilated. Univariate analysis showed an association with ICU mortality for mean glucose (non-survivors 8.6 +/- 4.3 vs 7.2 +/- 2.4 survivors), maximum glucose (11.7 +/- 5.9 vs 9.6 +/- 5.2, non-survivors vs survivors, respectively), use of insulin (mortality 29 vs 17% in patients not using insulin) and age (61 vs 55.7 years). Gender and a history of diabetes mellitus were not associated with mortality. In a multivariate model, the Apache-II score was the only variable associated with mortality independent of other variables, including mean blood glucose.
conclusionIn this retrospective study mean glucose level was not an independent risk factor for mortality in mixed ICU patients.
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