ArticleIntensive care medicine2006
Candida sp. isolated from bronchoalveolar lavage: clinical significance in critically ill trauma patients.
Article in Intensive care medicine, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- Impact of selective digestive decontamination on respiratory tract Candida among patients with suspected ventilator-associated pneumonia. A meta-analysis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2016Pooled it
- Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016Guideline
- Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2009Guideline
- Impact of Candida species on clinical outcomes in patients with suspected ventilator-associated pneumonia.Canadian respiratory journalTrial
- Identification and assessment of antifungal susceptibility ofIranian journal of microbiology · 2024Article
- Positive sputum culture ofChinese medical journal pulmonary and critical care medicine · 2023Article
- Candida pneumonia in young and immunocompetent lady: A case report and literature review.IDCases · 2023Article
- Treatments and Outcomes of Critically Ill Patients withThe Canadian journal of hospital pharmacy · 2023Article
- Diagnosis of lung squamous cell carcinoma based on metagenomic Next-Generation Sequencing.BMC pulmonary medicine · 2022Article
- Bronchoscopy Findings of Severe and Critical COVID-19 Patients Treated in ICU: A Year of Experience in a Developing Country.The open respiratory medicine journal · 2022Article
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- Measuring (1,3)-β-D-glucan in tracheal aspirate, bronchoalveolar lavage fluid, and serum for detection of suspected Candida pneumonia in immunocompromised and critically ill patients: a prospective observational study.BMC infectious diseases · 2017Observational
- Candida pneumonia in intensive care unit?Open forum infectious diseases · 2014Article
- Invasive fungal infections in patients with cancer in the Intensive Care Unit.International journal of antimicrobial agents · 2012Review
- Short term Candida albicans colonization reduces Pseudomonas aeruginosa-related lung injury and bacterial burden in a murine model.Critical care (London, England) · 2011Article
- Genetic relationships between Candida albicans strains isolated from dental plaque, trachea, and bronchoalveolar lavage fluid from mechanically ventilated intensive care unit patients.Journal of oral microbiology · 2011Article
- [Update: invasive fungal infections: Diagnosis and treatment in surgical intensive care medicine].Der Anaesthesist · 2010Review
- Mycoses in the elderly.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2010Review
- Impact of antifungal treatment on Candida-Pseudomonas interaction: a preliminary retrospective case-control study.Intensive care medicine · 2007Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveBased on limited data, Candida sp. isolates from bronchoalveolar lavage (BAL) cultures in immunocompetent patients are thought to be contaminants rather than pathogens. The objective of this study was to determine the clinical significance of Candida sp. isolated from BAL cultures in critically ill trauma patients. DESIGN AND
settingRetrospective study in a level 1 trauma intensive care unit. PATIENTS AND
participantsAll patients with Candida sp. isolated from BAL cultures over a 3-year period; 85 Candida positive BAL cultures from 62 patients were studied. MEASUREMENTS AND
resultsThe primary outcomes were the incidence of Candida sp. in BAL, antifungal use, course of the possible infection, and mortality. Of 1077 BAL cultures 85 (8%) grew Candida sp., representing 64 episodes of possible Candida sp. ventilator-associated pneumonia. No colony counts exceeded the diagnostic threshold for bacterial VAP (>or=10(5) cfu/ml). Only 2 of 64 episodes (3%) were treated with systemic antifungals. Three other episodes (5%) were treated because of concomitant therapy for Candida sp. at other sites. The majority of episodes were not treated with antifungals and were considered contaminants (59/64, 92%). No patients developed subsequent candidemia, and most follow-up BALs (74%) were negative for Candida sp. Overall mortality (17%) was similar to previous patients with similar severity of injury at the study center (18%).
conclusionsThe results of this study suggest that isolation of Candida sp. from BAL in quantities below the diagnostic threshold for VAP in this population does not require antifungal therapy.
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