ArticlePLoS genetics2006
Permissive transcriptional activity at the centromere through pockets of DNA hypomethylation.
Article in PLoS genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 72 citations in OpenAlex.
- Haplotype-resolved DiMeLo-seq maps centromeric chromatin in a complete diploid human genome.Cell genomics · 2026Article
- A genomic and epigenomic view of human centromeres.Nature reviews. Genetics · 2026Review
- Genomic and epigenomic maps of mouse centromeres and pericentromeres.Nature communications · 2025Article
- CENP-A: A Histone H3 Variant with Key Roles in Centromere Architecture in Healthy and Diseased States.Results and problems in cell differentiation · 2022Article
- Methylation status of hypothalamicFrontiers in endocrinology · 2022Article
- Genome-Wide Association Studies Identifying Multiple Loci Associated With Alfalfa Forage Quality.Frontiers in plant science · 2021Article
- Genetic and epigenetic effects on centromere establishment.Chromosoma · 2020Review
- Article
- Review
- Epigenetic activation of POTE genes in ovarian cancer.Epigenetics · 2019Article
- Selective modulation of local linkages between active transcription and oxidative demethylation activity shapes cardiomyocyte-specific gene-body epigenetic status in mice.BMC genomics · 2018Article
- The Hidden Genomic and Transcriptomic Plasticity of Giant Marker Chromosomes in Cancer.Genetics · 2018Article
- Epigenetic Regulation of Centromere Chromatin Stability by Dietary and Environmental Factors.Advances in nutrition (Bethesda, Md.) · 2017Review
- Neocentromeres to the Rescue of Acentric Chromosome Fragments.Molecular syndromology · 2017Article
- Formation of a functional maize centromere after loss of centromeric sequences and gain of ectopic sequences.The Plant cell · 2013Article
- Efficient neocentromere formation is suppressed by gene conversion to maintain centromere function at native physical chromosomal loci in Candida albicans.Genome research · 2013Article
- Environmental toxicants, epigenetics, and cancer.Advances in experimental medicine and biology · 2013Review
- Neocentromeres and epigenetically inherited features of centromeres.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2012Review
- Active transcription and essential role of RNA polymerase II at the centromere during mitosis.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Major chromosomal breakpoint intervals in breast cancer co-localize with differentially methylated regions.Frontiers in oncology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA methylation is a hallmark of transcriptional silencing, yet transcription has been reported at the centromere. To address this apparent paradox, we employed a fully sequence-defined ectopic human centromere (or neocentromere) to investigate the relationship between DNA methylation and transcription. We used sodium bisulfite PCR and sequencing to determine the methylation status of 2,041 CpG dinucleotides distributed across a 6.76-Mbp chromosomal region containing a neocentromere. These CpG dinucleotides were associated with conventional and nonconventional CpG islands. We found an overall hypermethylation of the neocentric DNA at nonconventional CpG islands that we designated as CpG islets and CpG orphans. The observed hypermethylation was consistent with the presence of a presumed transcriptionally silent chromatin state at the neocentromere. Within this neocentric chromatin, specific sites of active transcription and the centromeric chromatin boundary are defined by DNA hypomethylation. Our data demonstrate, for the first time to our knowledge, a correlation between DNA methylation and centromere formation in mammals, and that transcription and "chromatin-boundary activity" are permissible at the centromere through the selective hypomethylation of pockets of sequences without compromising the overall silent chromatin state and function of the centromere.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.