ArticleThe Journal of cell biology2006
A repeated IMP-binding motif controls oskar mRNA translation and anchoring independently of Drosophila melanogaster IMP.
Article in The Journal of cell biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 74 citations in OpenAlex.
- Structural and functional organization of germ plasm condensates.The Biochemical journal · 2022Review
- The long noncoding RNAScience advances · 2022Article
- Imp interacts with Lin28 to regulate adult stem cell proliferation in the Drosophila intestine.PLoS genetics · 2022Article
- Patterning the Drosophila embryo: A paradigm for RNA-based developmental genetic regulation.Wiley interdisciplinary reviews. RNA · 2020Review
- Article
- Makorin 1 controls embryonic patterning by alleviating Bruno1-mediated repression of oskar translation.PLoS genetics · 2020Article
- Neural stem cell temporal patterning and brain tumour growth rely on oxidative phosphorylation.eLife · 2019Article
- The prion-like domain of Drosophila Imp promotes axonal transport of RNP granules in vivo.Nature communications · 2019Article
- IMP regulates Kuzbanian to control the timing of Notch signalling inDevelopment (Cambridge, England) · 2019Article
- Drosophila Jak/STAT Signaling: Regulation and Relevance in Human Cancer and Metastasis.International journal of molecular sciences · 2018Review
- Cellular diversity in theeLife · 2018Article
- Review
- Bombyx mori P-element Somatic Inhibitor (BmPSI) Is a Key Auxiliary Factor for Silkworm Male Sex Determination.PLoS genetics · 2017Article
- Article
- Community effects in regulation of translation.eLife · 2016Article
- A Viral mRNA Motif at the 3'-Untranslated Region that Confers Translatability in a Cell-Specific Manner. Implications for Virus Evolution.Scientific reports · 2016Article
- Germ Plasm Biogenesis--An Oskar-Centric Perspective.Current topics in developmental biology · 2016Review
- RNA sequences required for the noncoding function of oskar RNA also mediate regulation of Oskar protein expression by Bicoid Stability Factor.Developmental biology · 2015Article
- Drosophila Imp iCLIP identifies an RNA assemblage coordinating F-actin formation.Genome biology · 2015Article
- MicroRNA-340-mediated degradation of microphthalmia-associated transcription factor (MITF) mRNA is inhibited by coding region determinant-binding protein (CRD-BP).The Journal of biological chemistry · 2015Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Zip code-binding protein 1 (ZBP-1) and its Xenopus laevis homologue, Vg1 RNA and endoplasmic reticulum-associated protein (VERA)/Vg1 RNA-binding protein (RBP), bind repeated motifs in the 3' untranslated regions (UTRs) of localized mRNAs. Although these motifs are required for RNA localization, the necessity of ZBP-1/VERA remains unresolved. We address the role of ZBP-1/VERA through analysis of the Drosophila melanogaster homologue insulin growth factor II mRNA-binding protein (IMP). Using systematic evolution of ligands by exponential enrichment, we identified the IMP-binding element (IBE) UUUAY, a motif that occurs 13 times in the oskar 3'UTR. IMP colocalizes with oskar mRNA at the oocyte posterior, and this depends on the IBEs. Furthermore, mutation of all, or subsets of, the IBEs prevents oskar mRNA translation and anchoring at the posterior. However, oocytes lacking IMP localize and translate oskar mRNA normally, illustrating that one cannot necessarily infer the function of an RBP from mutations in its binding sites. Thus, the translational activation of oskar mRNA must depend on the binding of another factor to the IBEs, and IMP may serve a different purpose, such as masking IBEs in RNAs where they occur by chance. Our findings establish a parallel requirement for IBEs in the regulation of localized maternal mRNAs in D. melanogaster and X. laevis.
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