ArticleThe Journal of experimental medicine2006
Impaired response to Listeria in H2-M3-deficient mice reveals a nonredundant role of MHC class Ib-specific T cells in host defense.
Article in The Journal of experimental medicine, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Coincident epithelial signals restrain commensal-specific CD8αβbioRxiv : the preprint server for biology · 2026Article
- Food antigens suppress small intestinal tumorigenesis.Frontiers in immunology · 2024Article
- Recognition ofInnate immunity · 2023Review
- MAITs and their mates: "Innate-like" behaviors in conventional and unconventional T cells.Clinical and experimental immunology · 2023Article
- Innate and Innate-like Effector Lymphocytes in Health and Disease.Journal of immunology (Baltimore, Md. : 1950) · 2022Review
- Immunotherapeutic Value of MAP1LC3C and Its Candidate FDA-Approved Drugs Identified by Pan-Cancer Analysis, Virtual Screening and Sensitivity Analysis.Frontiers in pharmacology · 2022Article
- Preface: Unconventional T Cells in Health and Disease.Critical reviews in immunology · 2021Article
- Origin and evolution of the major histocompatibility complex class I region in eutherian mammals.Ecology and evolution · 2019Article
- Innate and Adaptive Immune Responses duringMicrobiology spectrum · 2019Article
- Review
- The role of MHC class Ib-restricted T cells during infection.Immunogenetics · 2016Review
- Expression and alternative splicing of classical and nonclassical MHCI genes in the hippocampus and neuromuscular junction.Molecular and cellular neurosciences · 2016Article
- Dissecting CD8+ NKT Cell Responses to Listeria Infection Reveals a Component of Innate Resistance.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- CXCR3 expression defines a novel subset of innate CD8+ T cells that enhance immunity against bacterial infection and cancer upon stimulation with IL-15.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- Expression of the mouse MHC class Ib H2-T11 gene product, a paralog of H2-T23 (Qa-1) with shared peptide-binding specificity.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Ly49 receptors: innate and adaptive immune paradigms.Frontiers in immunology · 2014Review
- Non-classical MHC Class I molecules regulating natural killer cell function.Oncoimmunology · 2013Article
- Recognition of the nonclassical MHC class I molecule H2-M3 by the receptor Ly49A regulates the licensing and activation of NK cells.Nature immunology · 2012Article
- Nonclassical NK cell education.Nature immunology · 2012Article
- SAP is required for the development of innate phenotype in H2-M3--restricted Cd8(+) T cells.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
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Authors and funding
5 authors.
Funding
Abstract
The major histocompatibility complex (MHC) class Ib molecule H2-M3 primes the rapid expansion of CD8+ T cells by presenting N-formylated bacterial peptides. However, the significance of H2-M3-restricted T cells in host defense against bacteria is unclear. We generated H2-M3-deficient mice to investigate the role of H2-M3 in immunity against Listeria monocytogenes (LM), a model intracellular bacterial pathogen. H2-M3-deficient mice are impaired in early bacterial clearance during primary infection, with diminished LM-specific CD8+ T cell responses and compromised innate immune functions. Although H2-M3-restricted CD8+ T cells constitute a significant proportion of the anti-listerial CD8+ T cell repertoire, the kinetics and magnitude of MHC class Ia-restricted T cell responses are not altered in H2-M3-deficient mice. The fact that MHC class Ia-restricted responses cannot compensate for the H2-M3-mediated immunity suggests a nonredundant role of H2-M3 in the protective immunity against LM. Thus, the early H2-M3-restricted response temporally bridges the gap between innate and adaptive immune responses, subsequently affecting the function of both branches of the immune system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.