Trial reportAnnals of the rheumatic diseases2006
Long term NSAID treatment inhibits COX-2 synthesis in the knee synovial membrane of patients with osteoarthritis: differential proinflammatory cytokine profile between celecoxib and aceclofenac.
Trial report in Annals of the rheumatic diseases, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 98 citations in OpenAlex.
- Effect of Celecoxib on Surgical Site Inflammation after Total Knee Arthroplasty: A Randomized Controlled Study.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2018Trial
- Evaluation of Mangosteen juice blend on biomarkers of inflammation in obese subjects: a pilot, dose finding study.Nutrition journal · 2009Trial
- Quercetin Reduces Antinociceptive but Not the Anti-Inflammatory Effects of Indomethacin, Ketorolac, and Celecoxib in Rats with Gout-like Pain.Molecules (Basel, Switzerland) · 2025Article
- Article
- Edge advances in nanodrug therapies for osteoarthritis treatment.Frontiers in pharmacology · 2024Review
- Review
- Imaging of Synovial Inflammation in Osteoarthritis, From theAJR. American journal of roentgenology · 2022Review
- Association between current medication use and progression of radiographic knee osteoarthritis: data from the osteoarthritis initiative.Rheumatology (Oxford, England) · 2021Observational
- Article
- The effects of twenty-four nutrients and phytonutrients on immune system function and inflammation: A narrative review.Journal of clinical and translational research · 2021Review
- The effective interplay of (non-) selective NSAIDs with neostigmine in animal models of analgesia and inflammation.BMC pharmacology & toxicology · 2021Article
- A Review of Aceclofenac: Analgesic and Anti-Inflammatory Effects on Musculoskeletal Disorders.Journal of pain research · 2021Review
- Therapeutic Manipulation of Macrophages Using Nanotechnological Approaches for the Treatment of Osteoarthritis.Nanomaterials (Basel, Switzerland) · 2020Review
- Beneficial effects of manually assisted chiropractic adjusting instrument in a rabbit model of osteoarthritis.Scientific reports · 2020Article
- Inhibitory effects of skate cartilage chondroitin sulfate-rich extract on the production of inflammatory mediators and ROS in lipopolysaccharide-treated murine macrophages: a comparison with shark cartilage chondroitin sulfate.In vitro cellular & developmental biology. Animal · 2020Article
- Macrophages in osteoarthritis: pathophysiology and therapeutics.American journal of translational research · 2020Article
- Penetration of topical diclofenac into synovial tissue and fluid of osteoarthritic knees: a multicenter, randomized, placebo-controlled, pharmacokinetic study.Therapeutic advances in musculoskeletal disease · 2020Article
- Inhibition of pSTAT1 by tofacitinib accounts for the early improvement of experimental chronic synovitis.Journal of inflammation (London, England) · 2019Article
- Increased synovial lipodystrophy induced by high fat diet aggravates synovitis in experimental osteoarthritis.Arthritis research & therapy · 2017Article
- Cross-Coupling Effects of Silencing of Cyclooxygenase-2 (COX-2)/Aggrecanase-1 and Over-Expressed Insulin-Like Growth Factor 1 (IGF-1) in an Osteoarthritis Animal Model.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo compare the effect of celecoxib with that of a classic non-steroidal anti-inflammatory drug (NSAID) on synovial inflammation and on the synovial expression of proinflammatory genes in patients with knee osteoarthritis (OA).
methods30 patients with severe knee OA scheduled for total knee replacement surgery were included in a 3 month clinical trial. They were randomised to two groups: patients treated with celecoxib (CBX) (200 mg/24 h) and patients treated with aceclofenac (ACF) (100 mg/12 h). Those patients with OA who did not want to be treated with NSAIDs served as a control group. During knee surgery, synovial fluid (SF) and synovial membrane (SM) were collected. A SM specimen was fixed and embedded in paraffin and another part was frozen for molecular biology studies.
resultsAt the end of study both CBX and ACF treated patients showed a significant improvement in pain and knee function compared with controls. Both drugs significantly reduced prostaglandin E(2) (PGE(2)) SF concentration and down regulated COX-2 mRNA and protein expression at the SM. However, synovial macrophage infiltration (CD68 antigen staining) and expression of proinflammatory mediators, such as interleukin 1beta and tumour necrosis factor alpha, were decreased only by CBX treatment.
conclusionBoth drugs improved joint pain and function, inhibited SF PGE(2) concentration, and induced a decrease in synovial COX-2 expression and synthesis not related to the tissue inflammatory status. These data suggest that PGE(2) blocking agents may decrease PGE(2) production not only by direct COX-2 inhibition but also by down regulating COX-2 expression and synthesis. However, CBX and ACF appear to have different anti-inflammatory profiles in controlling OA synovial macrophage infiltration and proinflammatory expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.