ArticleImmunology2006
Peritoneal macrophages suppress T-cell activation by amino acid catabolism.
Article in Immunology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 32 citations in OpenAlex.
- Review
- Understanding tissue-resident macrophages unlocks the potential for novel combinatorial strategies in breast cancer.Frontiers in immunology · 2024Review
- IgD ligation allows peritoneal cavity B cell proliferation.Immunobiology · 2022Article
- Tissue-Resident Innate Immune Cell-Based Therapy: A Cornerstone of Immunotherapy Strategies for Cancer Treatment.Frontiers in cell and developmental biology · 2022Review
- Review
- A TLR4-TRIF-dependent signaling pathway is required for protective natural tumor-reactive IgM production by B1 cells.Cancer immunology, immunotherapy : CII · 2020Article
- Activation of B-1 Cells Promotes Tumor Cell Killing in the Peritoneal Cavity.Cancer research · 2019Article
- PHA eludes macrophage suppression to activate CD8Immunobiology · 2019Article
- High macrophage PD-L1 expression not responsible for T cell suppression.Cellular immunology · 2018Article
- Brain Microglial Cells Are Highly Susceptible to HIV-1 Infection and Spread.AIDS research and human retroviruses · 2017Article
- Macrophage regulation of B cell proliferation.Cellular immunology · 2017Article
- Challenges and future perspectives of T cell immunotherapy in cancer.Immunology letters · 2015Review
- Tumor-associated vacuolar ATPase subunit promotes tumorigenic characteristics in macrophages.Oncogene · 2014Article
- HIF-1 Dimerization Inhibitor Acriflavine Enhances Antitumor Activity of Sunitinib in Breast Cancer Model.Oncology research · 2014Article
- CD28 ligation increases macrophage suppression of T-cell proliferation.Cellular & molecular immunology · 2012Article
- Macrophage expression of hypoxia-inducible factor-1 alpha suppresses T-cell function and promotes tumor progression.Cancer research · 2010Article
- Human peritoneal macrophages from ascitic fluid can be infected by a broad range of HIV-1 isolates.Journal of acquired immune deficiency syndromes (1999) · 2010Article
- Cytokine treatment of macrophage suppression of T cell activation.Immunobiology · 2010Article
- Macrophages in hepatitis B and hepatitis C virus infections.Journal of virology · 2009Review
- Special regulatory T-cell review: FOXP3 biochemistry in regulatory T cells--how diverse signals regulate suppression.Immunology · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
T-lymphocyte activation triggered by anti-CD3, endogenous or exogenous superantigen, and mitogens was suppressed in a cell-dose-dependent fashion by peritoneal cavity (PerC) leucocytes. Study of lymphocyte-deficient mice and the use of multiparameter fluorescence-activated cell sorter analyses revealed that macrophages were responsible for this form of immune regulation. Interferon-gamma was essential to trigger suppression, which, by enzyme inhibition studies, was shown to be the result of tryptophan and arginine catabolism. These results illustrate that macrophages, which are classically defined by their innate effector function as antigen-presenting cells, have the potential to temper adaptive immunity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.