ArticleJournal of virology2006
Crucial role of the 5' conserved structure of bamboo mosaic virus satellite RNA in downregulation of helper viral RNA replication.
Article in Journal of virology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- A special satellite-like RNA of a novel hypovirus from Pestalotiopsis fici broadens the definition of fungal satellite.PLoS pathogens · 2023Article
- Trade-off between local replication and long-distance dissemination during experimental evolution of a satellite RNA.Frontiers in microbiology · 2023Article
- Short 5' Untranslated Region Enables Optimal Translation of Plant Virus Tricistronic RNA via Leaky Scanning.Journal of virology · 2022Article
- Molecular interactions of plant viral satellites.Virus genes · 2021Review
- A conserved RNA structure is essential for a satellite RNA-mediated inhibition of helper virus accumulation.Nucleic acids research · 2019Article
- The Defense Response ofViruses · 2018Article
- Interfering Satellite RNAs ofFrontiers in microbiology · 2017Review
- Distribution of mutational fitness effects and of epistasis in the 5' untranslated region of a plant RNA virus.BMC evolutionary biology · 2015Article
- Biologically-supported structural model for a viral satellite RNA.Nucleic acids research · 2015Article
- Genetic diversity and evolution of satellite RNAs associated with the bamboo mosaic virus.PloS one · 2014Article
- Transgenic resistance to Bamboo mosaic virus by expression of interfering satellite RNA.Molecular plant pathology · 2013Article
- The conserved 5' apical hairpin stem loops of bamboo mosaic virus and its satellite RNA contribute to replication competence.Nucleic acids research · 2012Article
- Global analyses of small interfering RNAs derived from Bamboo mosaic virus and its associated satellite RNAs in different plants.PloS one · 2010Article
- Satellite RNAs and Satellite Viruses of Plants.Viruses · 2009Article
Corrections and comments
- Erratum issuedAnnamali, Padmanaban [corrected to Annamalai, Padmanaban]
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Satellite RNA of Bamboo mosaic virus (satBaMV), a single-stranded mRNA type satellite encoding a protein of 20 kDa (P20), depends on the helper BaMV for replication and encapsidation. Two satBaMV isolates, BSF4 and BSL6, exhibit distinctly differential phenotypes in Nicotiana benthamiana plants when coinoculated with BaMV RNA. BSL6 significantly reduces BaMV RNA replication and suppresses the BaMV-induced symptoms, whereas BSF4 does not. By studies with chimeric satBaMVs generated by exchanging the components between BSF4 and BSL6, the genetic determinants responsible for the downregulation of BaMV replication and symptom expression were mapped at the 5' untranslated region (UTR) of BSL6. The 5' UTR of BSL6 alone is sufficient to diminish BaMV RNA replication when the 5' UTR is inserted in cis into the BaMV expression vector or when coinoculation with mutants that block the synthesis of P20 protein takes place. Further, the 5' UTR of natural satBaMV isolates contains one hypervariable (HV) region which folds into a conserved apical hairpin stem-loop (AHSL) structure (W. B. Yeh, Y. H. Hsu, H. C. Chen, and N. S. Lin, Virology 330:105-115, 2004). Interchanges of AHSL segment of HV regions between BSF4 and BSL6 led to the ability of chimeric satBaMV to interfere with BaMV replication and symptom expression. The conserved secondary structure within the HV region is a potent determinant of the downregulation of helper virus replication.
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