ArticleJournal of virology2006
Potassium ion channels of Chlorella viruses cause rapid depolarization of host cells during infection.
Article in Journal of virology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 47 citations in OpenAlex.
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- Viral Complexity.Biomolecules · 2022Review
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- Incomplete tricarboxylic acid cycle and proton gradient in Pandoravirus massiliensis: is it still a virus?The ISME journal · 2022Article
- Identification of a Chlorovirus PBCV-1 Protein Involved in Degrading the Host Cell Wall during Virus Infection.Viruses · 2021Article
- Genetic Diversity of Potassium Ion Channel Proteins Encoded by Chloroviruses That InfectViruses · 2020Article
- Heterocyclic Inhibitors of Viroporins in the Design of Antiviral Compounds.Chemistry of heterocyclic compounds · 2020Article
- Chloroviruses.Viruses · 2019Review
- Structural studies demonstrating a bacteriophage-like replication cycle of the eukaryote-infecting Paramecium bursaria chlorella virus-1.PLoS pathogens · 2017Article
- Chloroviruses Have a Sweet Tooth.Viruses · 2017Review
- Evolution and Phylogeny of Large DNA Viruses,Frontiers in microbiology · 2016Article
- Engineering a Ca⁺⁺⁺-sensitive (bio)sensor from the pore-module of a potassium channel.Sensors (Basel, Switzerland) · 2015Article
- Article
- Deep RNA sequencing reveals hidden features and dynamics of early gene transcription in Paramecium bursaria chlorella virus 1.PloS one · 2014Article
- A virus-encoded potassium ion channel is a structural protein in the chlorovirus Paramecium bursaria chlorella virus 1 virion.The Journal of general virology · 2013Article
- Potassium ion channels: could they have evolved from viruses?Plant physiology · 2013Review
- Paramecium bursaria chlorella virus 1 proteome reveals novel architectural and regulatory features of a giant virus.Journal of virology · 2012Article
- Phycodnavirus potassium ion channel proteins question the virus molecular piracy hypothesis.PloS one · 2012Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
Abstract
Previous studies have established that chlorella viruses encode K(+) channels with different structural and functional properties. In the current study, we exploit the different sensitivities of these channels to Cs(+) to determine if the membrane depolarization observed during virus infection is caused by the activities of these channels. Infection of Chlorella NC64A with four viruses caused rapid membrane depolarization of similar amplitudes, but with different kinetics. Depolarization was fastest after infection with virus SC-1A (half time [t(1/2)], about 9 min) and slowest with virus NY-2A (t(1/2), about 12 min). Cs(+) inhibited membrane depolarization only in viruses that encode a Cs(+)-sensitive K(+) channel. Collectively, the results indicate that membrane depolarization is an early event in chlorella virus-host interactions and that it is correlated with viral-channel activity. This suggestion was supported by investigations of thin sections of Chlorella cells, which show that channel blockers inhibit virus DNA release into the host cell. Together, the data indicate that the channel is probably packaged in the virion, presumably in its internal membrane. We hypothesize that fusion of the virus internal membrane with the host plasma membrane results in an increase in K(+) conductance and membrane depolarization; this depolarization lowers the energy barrier for DNA release into the host.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.