ArticleJournal of virology2006
Intrahepatic hepatitis C virus replication correlates with chronic hepatitis C disease severity in vivo.
Article in Journal of virology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 55 citations in OpenAlex.
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- Assessment of hepatitis C virus permissiveness in iteratively genetically humanized mice.Journal of virology · 2025Article
- HIV influences clustering and intracellular replication of hepatitis C virus.Journal of viral hepatitis · 2021Article
- Repeated spontaneous clearance of hepatitis C virus infection in the setting of long-term non-progression of HIV infection.Infectious disease reports · 2017Article
- Article
- Use of laser capture microdissection to map hepatitis C virus-positive hepatocytes in human liver.Gastroenterology · 2013Article
- Cell-cell contact-mediated hepatitis C virus (HCV) transfer, productive infection, and replication and their requirement for HCV receptors.Journal of virology · 2013Article
- The liver partition coefficient-corrected inhibitory quotient and the pharmacokinetic-pharmacodynamic relationship of directly acting anti-hepatitis C virus agents in humans.Antimicrobial agents and chemotherapy · 2012Article
- Increased microRNA-155 expression in the serum and peripheral monocytes in chronic HCV infection.Journal of translational medicine · 2012Article
- Hepatitis C virus proteins inhibit C3 complement production.Journal of virology · 2012Article
- Human cell types important for hepatitis C virus replication in vivo and in vitro: old assertions and current evidence.Virology journal · 2011Review
- Hepatitis C virus induces oxidative stress, DNA damage and modulates the DNA repair enzyme NEIL1.Journal of gastroenterology and hepatology · 2010Article
- Kupffer cells are depleted with HIV immunodeficiency and partially recovered with antiretroviral immune reconstitution.AIDS (London, England) · 2009Article
- Article
- A mathematical model of hepatitis C virus dynamics in patients with high baseline viral loads or advanced liver disease.Gastroenterology · 2009Article
- Genomic analysis reveals a potential role for cell cycle perturbation in HCV-mediated apoptosis of cultured hepatocytes.PLoS pathogens · 2009Article
- Persistence of hepatitis C RNA in liver allografts is associated with histologic progression independent of serologic viral clearance.Journal of transplantation · 2009Article
- Hepatitis C virus envelope glycoprotein co-evolutionary dynamics during chronic hepatitis C.Virology · 2008Article
- Molecular and bioinformatic evidence of hepatitis C virus evolution in brain.The Journal of infectious diseases · 2008Article
- Hepatitis C Viral Kinetics in Special Populations.Current hepatitis reports · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
The role of viral factors in the pathogenesis of chronic hepatitis C is unknown. The objective of the present study was to characterize markers of hepatitis C virus (HCV) infection and replication in liver biopsy specimens obtained from 65 genotype 1-infected subjects, including 31 who were coinfected with human immunodeficiency virus (HIV), and to analyze associations between intrahepatic viral markers and hepatitis C disease severity. The percentages of liver cells harboring HCV genomes (%G) and replicative-intermediate RNAs (%RI) were evaluated using strand-specific in situ hybridization, while HCV core and NS3 antigens were assessed by immunocytochemistry. HIV-positive and HIV-negative subjects had similar mean grades and stages of liver disease and had similar indices of HCV infection and replication in liver, even though coinfected subjects had significantly shorter mean disease duration (P = 0.0003). Multivariate analysis showed that %G was not associated with grade or stage of liver disease (P = 0.5 and 0.4, respectively), while %RI was strongly associated with liver inflammation (P < 0.001), liver fibrosis (P < 0.001), and serum alanine aminotransferase levels (P = 0.01). NS3 antigen (but not core) was more frequently detected in HCV RI-positive versus RI-negative specimens (P = 0.028). These findings demonstrate a link between HCV proliferation and hepatitis C disease severity and suggest similar pathogenic mechanisms in HIV-positive and HIV-negative individuals.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.