ArticleAmerican journal of respiratory cell and molecular biology2006
Tissue-specific renin-angiotensin system in pulmonary lymphangioleiomyomatosis.
Article in American journal of respiratory cell and molecular biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Clinical utility of diagnostic guidelines and putative biomarkers in lymphangioleiomyomatosis.Respiratory research · 2012Trial
- Lymphangioleiomyomatosis: a metastatic lung disease.American journal of physiology. Cell physiology · 2023Review
- Histamine signaling and metabolism identify potential biomarkers and therapies for lymphangioleiomyomatosis.EMBO molecular medicine · 2021Article
- Lung Adenocarcinoma Syndecan-2 Potentiates Cell Invasiveness.American journal of respiratory cell and molecular biology · 2019Article
- Angiotensin-converting enzyme inhibitors may affect pulmonary function in lymphangioleiomyomatosis.JCI insight · 2019Article
- The Lymphangioleiomyomatosis Lung Cell and Its Human Cell Models.American journal of respiratory cell and molecular biology · 2018Review
- Roles of the Angiotensin System in Neonatal Lung Injury and Disease.JSM atherosclerosis · 2016Article
- Article
- Microscopic validation of macroscopic in vivo images enabled by same-slide optical and nuclear fusion.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2014Article
- Evidence for pericyte origin of TSC-associated renal angiomyolipomas and implications for angiotensin receptor inhibition therapy.American journal of physiology. Renal physiology · 2014Article
- Osteoprotegerin contributes to the metastatic potential of cells with a dysfunctional TSC2 tumor-suppressor gene.The American journal of pathology · 2013Article
- Optimizing treatments for lymphangioleiomyomatosis.Expert review of respiratory medicine · 2012Review
- Antenatal maternal hypoxic stress: adaptations of the placental renin-angiotensin system in the mouse.Placenta · 2011Article
- Antenatal maternal hypoxic stress: adaptations in fetal lung Renin-Angiotensin system.Reproductive sciences (Thousand Oaks, Calif.) · 2011Article
- Erythropoietin-driven proliferation of cells with mutations in the tumor suppressor gene TSC2.American journal of physiology. Lung cellular and molecular physiology · 2011Article
- The natural history of lymphangioleiomyomatosis: markers of severity, rate of progression and prognosis.Lymphatic research and biology · 2010Article
- Lymphangioleiomyomatosis and TSC2-/- cells.Lymphatic research and biology · 2010Review
- Involvement of lymphatics in lymphangioleiomyomatosis.Lymphatic research and biology · 2009Article
- Article
- Lymphatic involvement in lymphangioleiomyomatosis.Annals of the New York Academy of Sciences · 2008Review
Corrections and comments
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Authors and funding
10 authors at 1 institution in 3 countries.
Funding
Abstract
Lymphangioleiomyomatosis (LAM), a multisystem disease found in middle-aged women, is characterized by cystic lung destruction and abdominal tumors (e.g., angiomyolipomas, lymphangioleimyomas), resulting from proliferation of abnormal-appearing, smooth muscle-like cells (LAM cells). The LAM cells, in combination with other cells, form nodular structures within the lung interstitium and in the walls of the cysts. LAM cells contain mutations in the tuberous sclerosis complex TSC1 and/or TSC2 genes, which lead to dysregulation of the mammalian target of rapamycin, affecting cell growth and proliferation. Proliferation and migration of vascular smooth muscle cells and production of angiogenic factors are regulated, in part, by angiotensin II. To determine whether a LAM-specific renin-angiotensin system might play a role in the pathogenesis of LAM, we investigated the expression of genes and gene products of this system in LAM nodules. mRNA for angiotensinogen was present in RNA isolated by laser-captured microdissection from LAM nodules. Angiotensin I-converting enzyme and chymase-producing mast cells were present within the LAM nodules. We detected renin in LAM cells, as determined by the presence of mRNA and immunohistochemistry. Angiotensin II type 1 and type II receptors were identified in LAM cells by immunohistochemistry and immunoblotting of microdissected LAM nodules. Angiotensin II is localized in cells containing alpha-smooth muscle actin (LAM cells). A LAM-specific renin-angiotensin system appears to function within the LAM nodule as an autocrine system that could promote LAM cell proliferation and migration, and could represent a pharmacologic target.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.