ArticleJournal of clinical microbiology1991
Neutralizing antibodies to heterologous animal rotavirus serotypes 5, 6, 7, and 10 in sera from Ecuadorian children.
Article in Journal of clinical microbiology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Prevalence of neutralizing antibodies against different rotavirus serotypes in children with severe rotavirus-induced diarrhea and their mothers.Clinical and diagnostic laboratory immunology · 2004Article
- Glycosphingolipid binding specificities of rotavirus: identification of a sialic acid-binding epitope.Journal of virology · 2001Article
- Detection of rotavirus types G8 and G10 among Brazilian children with diarrhea.Journal of clinical microbiology · 1998Article
- Bovine rotavirus 993/83 shows a third subtype of avian VP7 protein.Virus genes · 1997Article
- Effect of malnutrition on serum and milk antibodies in Zairian women.Clinical and diagnostic laboratory immunology · 1996Article
- Rotavirus serotype G5 associated with diarrhea in Brazilian children.Journal of clinical microbiology · 1994Article
- Detection of rotavirus serotypes G1, G2, G3, and G11 in feces of diarrheic calves by using polymerase chain reaction-derived cDNA probes.Journal of clinical microbiology · 1993Article
- Rotavirus-inhibitory activity in serial milk samples from Mexican women and rotavirus infections in their children during their first year of life.Journal of clinical microbiology · 1993Article
- Neutralizing serum antibodies to serotype 6 human rotaviruses PA151 and PA169 in Ecuadorian and German children.Journal of clinical microbiology · 1992Article
- Antibodies to seven rotavirus serotypes in cord sera, maternal sera, and colostrum of German women.Journal of clinical microbiology · 1991Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Serum samples from 870 Ecuadorian children who underwent natural rotavirus exposure were tested for neutralizing serum antibody to heterologous animal rotavirus (RV) serotypes. Six percent of the sera neutralized porcine RV OSU (serotype 5), 10% neutralized bovine RV NCDV (serotype 6), 4% neutralized avian RV Ch-2 (serotype 7), and 8% neutralized bovine RV V1005 (serotype 10). Neutralization was defined as a 90% reduction in infectious virus at a 1:100 serum dilution. The prevalence of antibody to all four heterotypic viruses increased with the age of the children and the number of human RV serotypes neutralized, but prevalences did not differ significantly between children from rural and urban areas of Ecuador. No serum sample that specifically neutralized bovine RV NCDV was identified. We inferred from the seroepidemiological analysis that human RVs contain immunorecessive neutralization epitopes that can stimulate cross-neutralizing antibody to heterotypic animal RVs. This occurs increasingly with age and with the number of human serotypes recognized by a child's neutralizing antibody. Thus, it appears that a broadened immune response to the heterotypic strains occurs with repetitive RV infections.
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