ArticleProceedings of the National Academy of Sciences of the United States of America2006
Frequency selectivity of synaptic exocytosis in frog saccular hair cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 59 citations in OpenAlex.
- Article
- Transient frequency preference responses in cell signaling systems.NPJ systems biology and applications · 2024Article
- Optogenetics and electron tomography for structure-function analysis of cochlear ribbon synapses.eLife · 2022Article
- VGLUT3-p.A211V variant fuses stereocilia bundles and elongates synaptic ribbons.The Journal of physiology · 2021Article
- Encoding sound in the cochlea: from receptor potential to afferent discharge.The Journal of physiology · 2021Review
- Nanomachinery Organizing Release at Neuronal and Ribbon Synapses.International journal of molecular sciences · 2019Review
- Voltage-Gated Calcium Channels: Key Players in Sensory Coding in the Retina and the Inner Ear.Physiological reviews · 2018Review
- Mechanisms of synaptic depression at the hair cell ribbon synapse that support auditory nerve function.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Article
- The Coupling between CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Actin Filaments Regulate Exocytosis at the Hair Cell Ribbon Synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Calcium-induced calcium release supports recruitment of synaptic vesicles in auditory hair cells.Journal of neurophysiology · 2016Article
- Relating structure and function of inner hair cell ribbon synapses.Cell and tissue research · 2015Review
- Hair cell-type dependent expression of basolateral ion channels shapes response dynamics in the frog utricle.Frontiers in cellular neuroscience · 2015Article
- Proton-mediated block of Ca2+ channels during multivesicular release regulates short-term plasticity at an auditory hair cell synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Phase-locking precision is enhanced by multiquantal release at an auditory hair cell ribbon synapse.Neuron · 2014Article
- Developmental refinement of hair cell synapses tightens the coupling of Ca2+ influx to exocytosis.The EMBO journal · 2014Article
- Single Ca2+ channels and exocytosis at sensory synapses.The Journal of physiology · 2013Review
- Tuning and timing in mammalian type I hair cells and calyceal synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Frequency-selective exocytosis by ribbon synapses of hair cells in the bullfrog's amphibian papilla.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The ability to respond selectively to particular frequency components of sensory inputs is fundamental to signal processing in the ear. The frog (Rana pipiens) sacculus, which is used for social communication and escape behaviors, is an exquisitely sensitive detector of sounds and ground-borne vibrations in the 5- to 200-Hz range, with most afferent axons having best frequencies between 40 and 60 Hz. We monitored the synaptic output of saccular sensory receptors (hair cells) by measuring the increase in membrane capacitance (deltaC(m)) that occurs when synaptic vesicles fuse with the plasmalemma. Strong stepwise depolarization evoked an exocytic burst that lasted 10 ms and corresponded to the predicted capacitance of all docked vesicles at synapses, followed by a 20-ms delay before additional vesicle fusion. Experiments using weak stimuli, within the normal physiological range for these cells, revealed a sensitivity to the temporal pattern of membrane potential changes. Interrupting a weak depolarization with a properly timed hyperpolarization increased deltaC(m). Small sinusoidal voltage oscillations (+/-5 mV centered at -60 mV) evoked a deltaC(m) that corresponded to 95 vesicles per s at each synapse at 50 Hz but only 26 vesicles per s at 5 Hz and 27 vesicles per s at 200 Hz (perforated patch recordings). This frequency selectivity was absent for larger sinusoidal oscillations (+/-10 mV centered at -55 mV) and was largest for hair cells with the smallest sinusoidal-stimuli-evoked Ca2+ currents. We conclude that frog saccular hair cells possess an intrinsic synaptic frequency selectivity that is saturated by strong stimuli.
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