ArticleBiophysical journal2006
Measuring the elasticity of clathrin-coated vesicles via atomic force microscopy.
Article in Biophysical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Clathrin is an Intrinsic Driver of Membrane Fission.bioRxiv : the preprint server for biology · 2026Article
- Dynamin-like Proteins Combine Mechano-constriction and Membrane Remodeling to Enable Two-Step Mitochondrial Fission via a "Snap-through" Instability.Journal of the American Chemical Society · 2025Article
- Article
- Nanodissected elastically loaded clathrin lattices relax to increased curvature.Science advances · 2021Article
- Endocytosis against high turgor pressure is made easier by partial coating and freely rotating base.Biophysical journal · 2021Article
- The AP2 adaptor enhances clathrin coat stiffness.The FEBS journal · 2019Article
- Actin assembly produces sufficient forces for endocytosis in yeast.Molecular biology of the cell · 2019Article
- Entry modes of ellipsoidal nanoparticles on a membrane during clathrin-mediated endocytosis.Soft matter · 2019Article
- Stochastic modeling of nanoparticle internalization and expulsion through receptor-mediated transcytosis.Nanoscale · 2019Article
- Differences in the metabolite composition and mechanical properties of extracellular vesicles secreted by hepatic cellular models.Journal of extracellular vesicles · 2019Article
- Stochastic simulations of nanoparticle internalization through transferrin receptor dependent clathrin-mediated endocytosis.Biochimica et biophysica acta. General subjects · 2018Article
- The role of traction in membrane curvature generation.Molecular biology of the cell · 2018Article
- Actin growth profile in clathrin-mediated endocytosis.Physical review. E · 2017Article
- Clathrin polymerization exhibits high mechano-geometric sensitivity.Soft matter · 2017Article
- Design principles for robust vesiculation in clathrin-mediated endocytosis.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Local Turgor Pressure Reduction via Channel Clustering.Biophysical journal · 2016Article
- Membrane remodeling and mechanics: Experiments and simulations of α-Synuclein.Biochimica et biophysica acta · 2016Review
- Numerical simulation of endocytosis: Viscous flow driven by membranes with non-uniformly distributed curvature-inducing molecules.Journal of computational physics · 2016Article
- Membrane Mechanics of Endocytosis in Cells with Turgor.PLoS computational biology · 2015Article
- Endocytic proteins drive vesicle growth via instability in high membrane tension environment.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
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Authors and funding
5 authors.
Funding
Abstract
Using a new scheme based on atomic force microscopy (AFM), we investigate mechanical properties of clathrin-coated vesicles (CCVs). CCVs are multicomponent protein and lipid complexes of approximately 100 nm diameter that are implicated in many essential cell-trafficking processes. Our AFM imaging resolves clathrin lattice polygons and provides height deformation in quantitative response to AFM-substrate compression force. We model CCVs as multilayered elastic spherical shells and, from AFM measurements, estimate their bending rigidity to be 285 +/- 30 k(B)T, i.e., approximately 20 times that of either the outer clathrin cage or inner vesicle membrane. Further analysis reveals a flexible coupling between the clathrin coat and the membrane, a structural property whose modulation may affect vesicle biogenesis and cellular function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.