ArticleBiophysical journal2006
A dynamic model of excitation-contraction coupling during acidosis in cardiac ventricular myocytes.
Article in Biophysical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 61 citations in OpenAlex.
- Type B Lactic Acidosis: Diagnosis, Etiology and Treatment - An Educational Review.Cardiology research · 2026Review
- Integrative simulation analysis of myocardial ischaemia-reperfusion injury.The Journal of physiology · 2026Article
- Extracellular acidification reveals the antiarrhythmic properties of amiodarone related to late sodium current-induced atrial arrhythmia.Pharmacological reports : PR · 2024Article
- A mathematical model of ENaC and Slc26a6 regulation by CFTR in salivary gland ducts.American journal of physiology. Gastrointestinal and liver physiology · 2024Article
- Risk of ventricular tachycardia and its outcomes in patients undergoing continuous renal replacement therapy due to acute kidney injury.Kidney research and clinical practice · 2023Article
- A Mathematical Model of Salivary Gland Duct Cells.Bulletin of mathematical biology · 2022Article
- The mitochondrial pyruvate carrier at the crossroads of intermediary metabolism.American journal of physiology. Endocrinology and metabolism · 2022Review
- Mathematical model of the ventricular action potential and effects of isoproterenol-induced cardiac hypertrophy in rats.European biophysics journal : EBJ · 2020Article
- Bond graph modelling of the cardiac action potential: implications for drift and non-unique steady states.Proceedings. Mathematical, physical, and engineering sciences · 2018Article
- Creating a Structurally Realistic Finite Element Geometric Model of a Cardiomyocyte to Study the Role of Cellular Architecture in Cardiomyocyte Systems Biology.Journal of visualized experiments : JoVE · 2018Article
- The Resting Potential and KFrontiers in physiology · 2018Article
- Computational modeling of epithelial fluid and ion transport in the parotid duct after transfection of human aquaporin-1.American journal of physiology. Gastrointestinal and liver physiology · 2017Article
- Mechanisms Underlying the Emergence of Post-acidosis Arrhythmia at the Tissue Level: A Theoretical Study.Frontiers in physiology · 2017Article
- Article
- Changes in Intracellular Na+ following Enhancement of Late Na+ Current in Virtual Human Ventricular Myocytes.PloS one · 2016Article
- A spatial model of fluid recycling in the airways of the lung.Journal of theoretical biology · 2015Article
- Regulation of cardiac cellular bioenergetics: mechanisms and consequences.Physiological reports · 2015Article
- β-adrenergic effects on cardiac myofilaments and contraction in an integrated rabbit ventricular myocyte model.Journal of molecular and cellular cardiology · 2015Article
- Dietary supplementation with either saturated or unsaturated fatty acids does not affect the mechanoenergetics of the isolated rat heart.Physiological reports · 2014Article
- Modulation of ventricular transient outward K⁺ current by acidosis and its effects on excitation-contraction coupling.American journal of physiology. Heart and circulatory physiology · 2013Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Acidosis in cardiac myocytes is a major factor in the reduced inotropy that occurs in the ischemic heart. During acidosis, diastolic calcium concentration and the amplitude of the calcium transient increase, while the strength of contraction decreases. This has been attributed to the inhibition by protons of calcium uptake and release by the sarcoplasmic reticulum, to a rise of intracellular sodium caused by activation of sodium-hydrogen exchange, decreased calcium binding affinity to Troponin-C, and direct effects on the contractile machinery. The relative contributions and concerted action of these effects are, however, difficult to establish experimentally. We have developed a mathematical model to examine altered calcium-handling mechanisms during acidosis. Each of the alterations was incorporated into a dynamical model of pH regulation and excitation-contraction coupling to predict the time courses of key ionic species during acidosis, in particular intracellular pH, sodium and the calcium transient, and contraction. This modeling study suggests that the most significant effects are elevated sodium, inhibition of sodium-calcium exchange, and the direct interaction of protons with the contractile machinery; and shows how the experimental data on these contributions can be reconciled to understand the overall effects of acidosis in the beating heart.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.