ReviewCurrent opinion in immunology2006
Chromatin structure and gene regulation in T cell development and function.
Review in Current opinion in immunology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Single-cell detection of primary transcripts, their genomic loci and nuclear factors by 3D immuno-RNA/DNA FISH in T cells.Frontiers in immunology · 2023Article
- Identification of histone acetylation markers in human fetal brains and increased H4K5ac expression in neural tube defects.Molecular genetics & genomic medicine · 2019Article
- Neuroendocrine regulation of inflammation.Seminars in immunology · 2014Review
- Developmental heterogeneity in DNA packaging patterns influences T-cell activation and transmigration.PloS one · 2012Article
- Child health, developmental plasticity, and epigenetic programming.Endocrine reviews · 2011Review
- Article
- Changes in histone acetylation and methylation that are important for persistent but not transient expression of CCR4 in human CD4+ T cells.European journal of immunology · 2010Article
- Making memories that last a lifetime: heritable functions of self-renewing memory CD8 T cells.International immunology · 2010Review
- Histone acetyltransferase CBP is vital to demarcate conventional and innate CD8+ T-cell development.Molecular and cellular biology · 2009Article
- T-bet dependent removal of Sin3A-histone deacetylase complexes at the Ifng locus drives Th1 differentiation.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Epigenetic principles and mechanisms underlying nervous system functions in health and disease.Progress in neurobiology · 2008Review
- Defective T-cell function leading to reduced antibody production in a kleisin-beta mutant mouse.Immunology · 2008Article
- Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates.The Journal of clinical investigation · 2008Article
- Heterogeneity in the CD4 T Cell Compartment and the Variability of Neonatal Immune Responsiveness.Current immunology reviews · 2007Article
- Thymic and extrathymic contributions to T helper cell function in murine neonates.Haematologica reports · 2006Article
- Programming CD8+ T cells for effective immunotherapy.Current opinion in immunology · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Transcription factors control gene expression programs in the context of the chromatin structure of their target genes. DNA methylation, post-translational histone modifications such as acetylation and methylation, and higher order chromatin organization allow the maintenance of gene expression patterns through mitosis, but how do they accommodate developmentally regulated changes in gene expression programs? Although histone acetylation and deacetylation are in dynamic equilibrium and mechanisms for the removal of methyl groups from histones are emerging, the extent to which there is active demethylation of DNA remains controversial. Looking at chromatin in the three-dimensional space of the nucleus, recent work demonstrates that gene regulation involves contacts between regulatory elements within genes or gene clusters on the same chromosome (in cis) and between different chromosomes (in trans). Finally, non-coding RNAs make a significant contribution to transcriptional and post-transcriptional gene silencing. Together, these advances contribute to an understanding of how gene expression programs are established, maintained and modified during development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.