ArticleNutrition & metabolism2006
Thyroid status influence on adiponectin, acylation stimulating protein (ASP) and complement C3 in hyperthyroid and hypothyroid subjects.
Article in Nutrition & metabolism, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 67 citations in OpenAlex.
- The impact of hypothyroidism on the risk of intrahepatic cholestasis of pregnancy: a large-scale study based on pregnant women with hypothyroidism in Shanghai, China.Journal of global health · 2026Article
- The relationship between serum CTRP-5, C3a/desArg, and complement-C3 levels and hypothyroidism in women with polycystic ovary syndrome.BMC endocrine disorders · 2024Article
- Co-Morbid Hypothyroidism and Liver Dysfunction: A Review.Clinical medicine insights. Endocrinology and diabetes · 2024Review
- Association between hypothyroidism and liver fibrosis risk: a systematic review and meta-analysis.Clinical and experimental hepatology · 2022Article
- Correlation between the thyroid hormone levels and nonalcoholic fatty liver disease in type 2 diabetic patients with normal thyroid function.BMC endocrine disorders · 2022Article
- The interplay between thyroid and liver: implications for clinical practice.Journal of endocrinological investigation · 2020Review
- Association of thyroid hormones with resting energy expenditure and complement C3 in normal weight high body fat women.Thyroid research · 2019Article
- A family with hypothyroidism caused by fatty acid synthase and apolipoprotein B receptor mutations.Molecular medicine reports · 2018Article
- Differences in the Plasma Proteome of Patients with Hypothyroidism before and after Thyroid Hormone Replacement: A Proteomic Analysis.International journal of molecular sciences · 2018Article
- Association of C5L2 genetic polymorphisms with coronary artery disease in a Han population in Xinjiang, China.Oncotarget · 2017Article
- Serum apelin levels in patients with thyroid dysfunction.International journal of clinical and experimental medicine · 2015Article
- Association between novel adipocytokines adiponectin, vaspin, visfatin, and thyroid: An experimental and clinical update.Endocrine connections · 2013Article
- Acylation stimulating protein reduction precedes insulin sensitization after BPD-DS bariatric surgery in severely obese women.Nutrition & diabetes · 2012Article
- Thyroid disorders and diabetes mellitus.Journal of thyroid research · 2011Article
- The effects of acylation stimulating protein supplementation VS antibody neutralization on energy expenditure in wildtype mice.BMC physiology · 2010Article
- Association of adipocyte genes with ASP expression: a microarray analysis of subcutaneous and omental adipose tissue in morbidly obese subjects.BMC medical genomics · 2010Article
- Metabolic impact on serum levels of complement component 3 in Japanese patients.Journal of clinical laboratory analysis · 2010Article
- Lipoprotein lipase deficiency is associated with elevated acylation stimulating protein plasma levels.Journal of lipid research · 2009Article
- Racial difference in Acylation Stimulating Protein (ASP) correlates to triglyceride in non-obese and obese African American and Caucasian women.Nutrition & metabolism · 2009Article
- Re: The metabolic syndrome is associated with circulating adipokines in older adults across a wide range of adiposity.The journals of gerontology. Series A, Biological sciences and medical sciences · 2009Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThyroid abnormalities (hyperthyroid and hypothyroid) are accompanied by changes in intermediary metabolism including alterations in body weight, insulin resistance and lipid profile. The aims of this study were to examine plasma ASP, its precursor C3 and adiponectin in hyperthyroid and hypothyroid subjects as compared to controls.
methodsA total of 99 subjects were recruited from endocrinology/out-patient clinics: 46 hyperthyroid subjects, 23 hypothyroid subjects and 30 control subjects. Subjects were evaluated for FT4, FT3, TSH, glucose, insulin, complete lipid profile and the adipokines: adiponectin, acylation stimulating protein (ASP) and complement C3.
resultsHyperthyroidism was associated with a 95% increase in adiponectin (p = 0.0002), a 47% decrease in C3 (p < 0.0001), no change in ASP and increased ASP/C3 ratio (p = 0.0012). Hypothyroidism was associated with a 31% increase in ASP (p = 0.008). Adiponectin and C3 correlated with FT3 (r = 0.383, p = 0.004 and r = -0.277, p = 0.007, respectively) and FT4 (r = 0.464, p = 0.003 and r = -0.225, p = 0.03, respectively). ASP correlated with TSH (r = 0.202, p = 0.04). Adiponectin did not correlate with either ASP or C3, only ASP and C3 correlated (r = -0.197, p = 0.05). Adiponectin was negatively correlated with BMI, total cholesterol and plasma triglyceride, while C3 was positively correlated with BMI and total cholesterol. Surprisingly, adiponectin was positively correlated with insulin (r = 0.293, p = 0.02) and HOMA-IR (r = 0.373, p = 0.003) while C3 was negatively correlated with glucose (r = -0.242, p = 0.022, insulin (r = -0.184, p = 0.05) and HOMA-IR.
conclusionThese changes suggest that thyroid disease may be accompanied by changes in adipokines, which may contribute to the phenotype expressed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.