ArticleBMC medical genetics2006
Genomic screen for loci associated with tobacco usage in Mission Indians.
Article in BMC medical genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Meta-analysis of 15 genome-wide linkage scans of smoking behavior.Biological psychiatry · 2010Pooled it
- Molecular genetics of nicotine dependence and abstinence: whole genome association using 520,000 SNPs.BMC genetics · 2007Trial
- Distinct Roles for Two Chromosome 1 Loci in Ethanol Withdrawal, Consumption, and Conditioned Place Preference.Frontiers in genetics · 2018Article
- Polygenic risk scores for cigarettes smoked per day do not generalize to a Native American population.Drug and alcohol dependence · 2016Article
- Evidence for a genetic component for substance dependence in Native Americans.The American journal of psychiatry · 2013Review
- Quantitative trait locus for body weight identified on rat chromosome 4 in inbred alcohol-preferring and -nonpreferring rats: potential implications for neuropeptide Y and corticotrophin releasing hormone 2.Alcohol (Fayetteville, N.Y.) · 2013Article
- Genome-wide linkage scan of antisocial behavior, depression, and impulsive substance use in the UCSF family alcoholism study.Psychiatric genetics · 2012Article
- Linkage analyses of stimulant dependence, craving, and heavy use in American Indians.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2011Article
- Linkage scan of nicotine dependence in the University of California, San Francisco (UCSF) Family Alcoholism Study.Psychological medicine · 2011Article
- A comparison of selected quantitative trait loci associated with alcohol use phenotypes in humans and mouse models.Addiction biology · 2010Review
- EEG alpha phenotypes: linkage analyses and relation to alcohol dependence in an American Indian community study.BMC medical genetics · 2010Article
- EEG spectral phenotypes: heritability and association with marijuana and alcohol dependence in an American Indian community study.Drug and alcohol dependence · 2010Article
- Genetic linkage findings for DSM-IV nicotine withdrawal in two populations.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2009Article
- Heritability and a genome-wide linkage analysis of a Type II/B cluster construct for cannabis dependence in an American Indian community.Addiction biology · 2009Article
- Article
- Externalizing disorders in American Indians: comorbidity and a genome wide linkage analysis.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2008Article
- Association between single nucleotide polymorphisms in the mu opioid receptor gene (OPRM1) and self-reported responses to alcohol in American Indians.BMC medical genetics · 2008Article
- Genome-wide linkage scan for nicotine dependence in European Americans and its converging results with African Americans in the Mid-South Tobacco Family sample.Molecular psychiatry · 2008Article
- Identifying susceptibility loci for nicotine dependence: 2008 update based on recent genome-wide linkage analyses.Human genetics · 2008Review
- Genomewide linkage survey of nicotine dependence phenotypes.Drug and alcohol dependence · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe prevalence of tobacco usage in Native American adults and adolescents is higher than any other racial or ethnic group, yet biological risk and protective factors underlying tobacco use in this ethnic group remain unknown. A genome scan for loci associated with tobacco use phenotypes was performed with data collected from a community sample of Mission Indians residing in Southwest California.
methodsA structured diagnostic interview was used to define two tobacco use phenotypes: 1) any regular tobacco usage (smoked daily for one month or more) and 2) persistent tobacco usage (smoked at least 10 cigarettes a day for more than one year). Heritability was determined and a linkage analysis was performed, using genotypes for a panel 791 microsatellite polymorphisms, for the two phenotypes using variance component methods implemented in SOLAR.
resultsAnalyses of multipoint variance component LOD scores for the two tobacco use phenotypes revealed two scores that exceeded 2.0 for the regular use phenotype: one on chromosomes 6 and one on 8. Four other loci on chromosomes 1,7,13, and 22 were found with LOD scores between 1.0 and 1.5. Two loci of interest were found on chromosomes 1 and 4 for the persistent use phenotype with LOD scores between 1.3-1.5. Bivariate linkage analysis was conducted at the site on chromosome 4 for persistent tobacco use and an alcohol drinking severity phenotype previously identified at this site. The maximum LOD score for the bivariate analysis for the region was 3.4, however, there was insufficient power to exclude coincident linkage.
conclusionWhile not providing evidence for linkage to specific chromosomal regions these results identify regions of interest in the genome in this Mission Indian population, for tobacco usage, some of which were identified in previous genome scans of non-native populations. Additionally, these data lend support for the hypothesis that cigarette smoking, alcohol dependence and other consumptive behaviors may share some common risk and/or protective factors in this Mission Indian population.
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