ArticleBMC genomics2006
Transcriptome analysis of a cnidarian-dinoflagellate mutualism reveals complex modulation of host gene expression.
Article in BMC genomics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 196 citations in OpenAlex.
- Symbiont-Mediated Metabolic Shift in the Sea Anemone Anthopleura elegantissima.Molecular ecology · 2025Article
- The Influence of Symbiont Identity on the Proteomic and Metabolomic Responses of the Model Cnidarian Aiptasia to Thermal Stress.Environmental microbiology · 2025Article
- Comparative transcriptomics revealed parallel evolution and innovation of photosymbiosis molecular mechanisms in a marine bivalve.Proceedings. Biological sciences · 2024Article
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- Spatial metabolomics for symbiotic marine invertebrates.Life science alliance · 2023Article
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- Symbiosis maintenance in the facultative coral, Oculina arbuscula, relies on nitrogen cycling, cell cycle modulation, and immunity.Scientific reports · 2021Article
- Insights into coral bleaching under heat stress from analysis of gene expression in a sea anemone model system.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Identification of scavenger receptors and thrombospondin-type-1 repeat proteins potentially relevant for plastid recognition in Sacoglossa.Ecology and evolution · 2020Article
- Receptors Mediating Host-Microbiota Communication in the Metaorganism: The Invertebrate Perspective.Frontiers in immunology · 2020Review
- Symbiotic lifestyle triggers drastic changes in the gene expression of the algal endosymbiontEcology and evolution · 2020Article
- The past, present, and future of coral heat stress studies.Ecology and evolution · 2019Review
- Proteomics quantifies protein expression changes in a model cnidarian colonised by a thermally tolerant but suboptimal symbiont.The ISME journal · 2019Article
- Global Shifts in Gene Expression Profiles Accompanied with Environmental Changes in Cnidarian-Dinoflagellate Endosymbiosis.G3 (Bethesda, Md.) · 2019Article
- Differential gene expression analysis of symbiotic and aposymbioticEcology and evolution · 2019Article
- Proteomic Basis of Symbiosis: A Heterologous Partner Fails to Duplicate Homologous Colonization in a Novel Cnidarian- Symbiodiniaceae Mutualism.Frontiers in microbiology · 2019Article
- Symbiont type and environmental factors affect transcriptome-wide gene expression in the coralEcology and evolution · 2019Article
- Symbiotic immuno-suppression: is disease susceptibility the price of bleaching resistance?PeerJ · 2018Article
- Relationship betweenPeerJ · 2018Article
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Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCnidarian-dinoflagellate intracellular symbioses are one of the most important mutualisms in the marine environment. They form the trophic and structural foundation of coral reef ecosystems, and have played a key role in the evolutionary radiation and biodiversity of cnidarian species. Despite the prevalence of these symbioses, we still know very little about the molecular modulators that initiate, regulate, and maintain the interaction between these two different biological entities. In this study, we conducted a comparative host anemone transcriptome analysis using a cDNA microarray platform to identify genes involved in cnidarian-algal symbiosis.
resultsWe detected statistically significant differences in host gene expression profiles between sea anemones (Anthopleura elegantissima) in a symbiotic and non-symbiotic state. The group of genes, whose expression is altered, is diverse, suggesting that the molecular regulation of the symbiosis is governed by changes in multiple cellular processes. In the context of cnidarian-dinoflagellate symbioses, we discuss pivotal host gene expression changes involved in lipid metabolism, cell adhesion, cell proliferation, apoptosis, and oxidative stress.
conclusionOur data do not support the existence of symbiosis-specific genes involved in controlling and regulating the symbiosis. Instead, it appears that the symbiosis is maintained by altering expression of existing genes involved in vital cellular processes. Specifically, the finding of key genes involved in cell cycle progression and apoptosis have led us to hypothesize that a suppression of apoptosis, together with a deregulation of the host cell cycle, create a platform that might be necessary for symbiont and/or symbiont-containing host cell survival. This first comprehensive molecular examination of the cnidarian-dinoflagellate associations provides critical insights into the maintenance and regulation of the symbiosis.
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