ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2006
The role of the forkhead transcription factor, Foxc1, in the development of the mouse lacrimal gland.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Understanding the development of oral epithelial organs through single cell transcriptomic analysis.Development (Cambridge, England) · 2022Article
- Dissecting the cellular specificity of smoking effects and reconstructing lineages in the human airway epithelium.Nature communications · 2020Article
- Generation of orthotopically functional salivary gland from embryonic stem cells.Nature communications · 2018Article
- Lacrimal gland development: From signaling interactions to regenerative medicine.Developmental dynamics : an official publication of the American Association of Anatomists · 2017Review
- Molecular Profiling of the Developing Lacrimal Gland Reveals Putative Role of Notch Signaling in Branching Morphogenesis.Investigative ophthalmology & visual science · 2017Article
- Foxc1 Ablated Mice Are Anhidrotic and Recapitulate Features of Human Miliaria Sweat Retention Disorder.The Journal of investigative dermatology · 2017Article
- Identification of transcription factors that promote the differentiation of human pluripotent stem cells into lacrimal gland epithelium-like cells.NPJ aging and mechanisms of disease · 2017Article
- FGF signaling activates a Sox9-Sox10 pathway for the formation and branching morphogenesis of mouse ocular glands.Development (Cambridge, England) · 2014Article
- Necessity of Smad4 for the normal development of the mouse lacrimal gland.Japanese journal of ophthalmology · 2014Article
- Transcription factors Runx1 to 3 are expressed in the lacrimal gland epithelium and are involved in regulation of gland morphogenesis and regeneration.Investigative ophthalmology & visual science · 2013Article
- Ocular surface development and gene expression.Journal of ophthalmology · 2013Article
- Conditional disruption of mouse Klf5 results in defective eyelids with malformed meibomian glands, abnormal cornea and loss of conjunctival goblet cells.Developmental biology · 2011Article
- Mechanisms involved in injury and repair of the murine lacrimal gland: role of programmed cell death and mesenchymal stem cells.The ocular surface · 2010Review
- Mechanisms of murine lacrimal gland repair after experimentally induced inflammation.Investigative ophthalmology & visual science · 2008Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The lacrimal gland produces secretions that lubricate and protect the cornea of the eye. Foxc1 encodes a forkhead/winged helix transcription factor required for the development of many embryonic organs. Autosomal dominant mutations in human FOXC1 cause eye disorders such as Axenfeld-Rieger Syndrome and glaucoma iris hypoplasia, resulting from malformation of the anterior segment of the eye. We show here that lacrimal gland development is severely impaired in homozygous null Foxc1 mouse mutants, with reduced outgrowth and branching. Foxc1 is expressed in both the epithelium of the lacrimal gland and the surrounding mesenchyme. FGF10 stimulates the growth and branching morphogenesis in cultures of wild type and Foxc1 mutant gland epithelial buds. However, using micromass culture of lacrimal gland mesenchyme, we show that Bmp7 induces wild type mesenchyme cells to aggregate, but Foxc1 mutant cells do not respond. This study demonstrates that Foxc1 mediates the BMP signaling required for lacrimal gland development.
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