Evidence map›Paper›PMID 16470417›Full record

ArticleParasitology research2006

Heterogeneity of class I and class II MHC sequences in Schistosoma mansoni.

Ayumi Okada, Atsuko Imase, Hajime Matsuda, Hiroshi Ohmae, Hidekazu Hata, Yukio Iwamura

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Parasitology research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Ayumi OkadaCenter for Arts and Humanities, Ibaraki Prefectural University of Health Sciences, Ami 4669-2, Ami, Inashiki, Ibaraki, 300-0394, Japan.
Atsuko Imase
Hajime Matsuda
Hiroshi Ohmae
Hidekazu Hata
Yukio Iwamura
Ibaraki Prefectural University of Health Sciences · JPDokkyo University · JPGunma University · JPUniversity of Tsukuba · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We investigated the genetic variations in class I and class II major histocompatibility complex (MHC) genes of Schistosoma mansoni and the effects of host MHC genotypes. S. mansoni was maintained in combinations of two mouse strains with different MHC genotypes, and the MHC gene sequences of the cercariae were investigated. The detected class I MHC gene sequences were variable, with high similarity between the H-2D(b) murine host and the parasite. For other combinations, however, the parasite sequence was homologous to those of anthropoids. All class II MHC sequences detected in S. mansoni were homologous to those of anthropoids. Our results suggest that the genetic variation in the MHC sequences of S. mansoni is derived in part from the current host, indicating horizontal transfer of the sequences from mammal to parasite.

Indexed as

AnimalsGenes, MHC Class IGenes, MHC Class IIGenetic VariationGene Transfer, HorizontalHost-Parasite InteractionsMaleMiceMice, Inbred BALB CMice, Inbred C57BLSchistosoma mansoniSpecies Specificity

Identifiers

PMID16470417
OpenAlexW2090367072

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.