ArticleFunctional & integrative genomics2006
Gene expression profiling of bovine in vitro adipogenesis using a cDNA microarray.
Article in Functional & integrative genomics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
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- Vertebrate SLRP family evolution and the subfunctionalization of osteoglycin gene duplicates in teleost fish.BMC evolutionary biology · 2018Article
- Cell-type-specific gene expression patterns in the knee cartilage in an osteoarthritis rat model.Functional & integrative genomics · 2018Article
- Adipogenic transcriptome profiling using high throughput technologies.Journal of genomics · 2013Review
- Skeletal muscle specific genes networks in cattle.Functional & integrative genomics · 2010Article
- Transcription profiling provides insights into gene pathways involved in horn and scurs development in cattle.BMC genomics · 2010Article
- Structural and functional-annotation of an equine whole genome oligoarray.BMC bioinformatics · 2009Article
- A differential wiring analysis of expression data correctly identifies the gene containing the causal mutation.PLoS computational biology · 2009Article
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- Epigenetic silencers are enriched in dormant desert frog muscle.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2008Article
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- Gene expression studies of developing bovine longissimus muscle from two different beef cattle breeds.BMC developmental biology · 2007Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gene expression profile of bovine bone marrow stromal cells undergoing adipogenesis was established using a custom cDNA microarray. Cells that were treated with adipogenic stimulants and those that were not were collected at each of the six time points, and gene expression differences between the treated and untreated samples within each time point were compared using a microarray. Statistical analyses revealed that 158 genes showed a minimum fold change of 2 in at least one of the five post-differentiation time points. These genes are involved in various cellular pathways and functions, including lipogenesis, glycolysis, cytoskeleton remodelling, extracellular matrix, transcription as well as various signalling pathways such as insulin, calcium and wingless signalling. The experiment also identified 17 differentially expressed (DE) microarray elements with no assigned function. Quantitative real-time PCR was employed to validate eight DE genes, and the PCR data were found to reproduce the microarray data for these eight genes. Subsequent gene ontology annotation was able to provide a global overview of the molecular function of DE genes during adipogenesis. This analysis was able to indicate the importance of different gene categories at various stages of adipogenic conversion, thereby providing further insights into the molecular changes during bovine adipogenesis.
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Registered trials
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