SynthesisEuropean child & adolescent psychiatry2006
Antipsychotics in early onset Schizophrenia: Systematic review and meta-analysis.
Synthesis in European child & adolescent psychiatry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 78 citations in OpenAlex.
- Quetiapine versus aripiprazole in children and adolescents with psychosis--protocol for the randomised, blinded clinical Tolerability and Efficacy of Antipsychotics (TEA) trial.BMC psychiatry · 2014Trial
- Review
- Mental Disorder Spectrum in Children and Adolescents from 2014-2022: A Nine-year Epidemiological and Clinical Trend.Current medical science · 2025Article
- Complex interplay of neurodevelopmental disorders (NDDs), fractures, and osteoporosis: a mendelian randomization study.BMC psychiatry · 2024Article
- Therapeutic drug monitoring in children and adolescents with schizophrenia and other psychotic disorders using risperidone.Journal of neural transmission (Vienna, Austria : 1996) · 2022Article
- Decision making under ambiguity and risk in adolescent-onset schizophrenia.BMC psychiatry · 2021Article
- Early-Stage Repetitive Transcranial Magnetic Stimulation Altered Posterior-Anterior Cerebrum Effective Connectivity in Methylazoxymethanol Acetate Rats.Frontiers in neuroscience · 2021Article
- Gender differences in the prevalence, comorbidities and antipsychotic prescription of early-onset schizophrenia: a nationwide population-based study in Taiwan.European child & adolescent psychiatry · 2019Article
- Tourette syndrome increases risk of bone fractures: a population-based cohort study.European child & adolescent psychiatry · 2017Article
- Comparing the ability of cognitive and affective Theory of Mind in adolescent onset schizophrenia.Neuropsychiatric disease and treatment · 2017Article
- Formal thought disorder in autism spectrum disorder predicts future symptom severity, but not psychosis prodrome.European child & adolescent psychiatry · 2015Article
- Impaired Verbal Learning Is Associated with Larger Caudate Volumes in Early Onset Schizophrenia Spectrum Disorders.PloS one · 2015Article
- Article
- Childhood-onset schizophrenia: what do we really know?Health psychology and behavioral medicine · 2014Article
- Weight gain and increase of body mass index among children and adolescents treated with antipsychotics: a critical review.European child & adolescent psychiatry · 2013Review
- Comparative effectiveness of second-generation antipsychotic medications in early-onset schizophrenia.Schizophrenia bulletin · 2012Article
- Mortality in children and adolescents prescribed antipsychotic medication: a retrospective cohort study using the UK general practice research database.Drug safety · 2011Article
- Engaging families in research to determine health literacy needs related to the use of second-generation antipsychotics in children and adolescents.Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent · 2010Article
- [Off-label use in child and adolescent psychiatry. An ongoing ethical, medical and legal problem].Der Nervenarzt · 2009Review
- Efficacy and tolerability of second-generation antipsychotics in children and adolescents with schizophrenia.Schizophrenia bulletin · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo develop an evidence base for using antipsychotic medications for schizophrenia in children and adolescents.
methodData sources were identified in PsychINFO (1872-2003), MEDLINE (1966-2003), and articles in reference lists. Study selection criteria: (1) treatment with antipsychotics; (2) ages were between 5 and 18 years; (3) sample diagnosed with schizophrenia; (4) prospective design; (5) rating instruments used. Fifteen studies met inclusion criteria and were rated. Study quality was independently rated.
resultsAverage response rate among 8 studies employing atypicals was 55.7% compared to 72.3% among 13 studies employing typicals. The difference was statistically different at the trend level (z = 1.65, P < 0.10). The effect size on a continuous measure was 0.36 in favor of typicals. When study quality was included in the model, the effect of medication type remained unchanged. Average weight gain in patients treated with typicals was 1.4 Kg. compared to 4.5 Kg for those treated with atypicals. Sedation was more common among those on atypicals. The rate of extrapyramidal side effects was similar among the two groups
conclusionsAntipsychotic medications seem effective for schizophrenia treatment in children and adolescents. Typicals appear to be more effective and cause less weight gain than atypicals. However, more rigorous clinical trials are necessary.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.