ArticleJournal of muscle research and cell motility2005
Muscle atrophy in titin M-line deficient mice.
Article in Journal of muscle research and cell motility, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 43 citations in OpenAlex.
- Mending the Achilles heels of titin in cardiac and musculoskeletal disease.Biophysical reviews · 2026Review
- Inflammation and Fatty Infiltration Correlates with Rotator Cuff Muscle Atrophy in Hypercholesterolemic Yucatan Microswine.Journal of orthopaedics and sports medicine · 2024Article
- Cholesterol: An Important Determinant of Muscle Atrophy in Astronauts.Journal of biotechnology and biomedicine · 2023Article
- Review
- Understanding the common mechanisms of heart and skeletal muscle wasting in cancer cachexia.Oncogenesis · 2021Review
- Titin mutations and muscle disease.Pflugers Archiv : European journal of physiology · 2019Review
- Alternative Splicing, Internal Promoter, Nonsense-Mediated Decay, or All Three: Explaining the Distribution of Truncation Variants in Titin.Circulation. Cardiovascular genetics · 2016Article
- Increasing Role of Titin Mutations in Neuromuscular Disorders.Journal of neuromuscular diseases · 2016Review
- Mechanical Signaling in the Pathophysiology of Critical Illness Myopathy.Frontiers in physiology · 2016Review
- Structure of giant muscle proteins.Frontiers in physiology · 2013Review
- At the Start of the Sarcomere: A Previously Unrecognized Role for Myosin Chaperones and Associated Proteins during Early Myofibrillogenesis.Biochemistry research international · 2012Article
- Interferon-stimulated gene 15 (ISG15) conjugates proteins in dermatomyositis muscle with perifascicular atrophy.Annals of neurology · 2010Article
- Altered contractility of skeletal muscle in mice deficient in titin's M-band region.Journal of molecular biology · 2009Article
- Calpain activity and muscle wasting in sepsis.American journal of physiology. Endocrinology and metabolism · 2008Review
- Early incorporation of obscurin into nascent sarcomeres: implication for myofibril assembly during cardiac myogenesis.Histochemistry and cell biology · 2008Article
- Cooperative control of striated muscle mass and metabolism by MuRF1 and MuRF2.The EMBO journal · 2008Article
- Regulation of skeletal muscle sarcomere integrity and postnatal muscle function by Mef2c.Molecular and cellular biology · 2007Article
- M line-deficient titin causes cardiac lethality through impaired maturation of the sarcomere.The Journal of cell biology · 2006Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
We investigated the response to deletion of the titin M-line region in striated muscle, using a titin knockout model and a range of techniques that include histology, in situ hybridization, electron microscopy, and 2D gel analysis. We found that the loss of titin's kinase domain and binding sites for myomesin and MURF-1 causes structural changes in the sarcomere that proceed from the M-line to the Z-disc and ultimately result in disassembly of the sarcomere. Disassembly goes along with central localization of nuclei (a hallmark for muscular dystrophy), up-regulation of heat-shock proteins, and induction of proteasome activity. While fiber type composition does not change in soleus and extensor digitorum longus muscle, fiber size is reduced. Animals die from complications of muscle atrophy at five weeks of age. In addition to the structural importance of the titin M-line region in any striated muscle, our data show how differences in M-line composition between heart and skeletal muscle affect sarcomere stability and function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.