ArticleEMBO reports2006
Type A and B RNase P RNAs are interchangeable in vivo despite substantial biophysical differences.
Article in EMBO reports, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 55 citations in OpenAlex.
- Suppression of theRNA (New York, N.Y.) · 2024Article
- Characterization of RNA-based and protein-only RNases P from bacteria encoding both enzyme types.RNA (New York, N.Y.) · 2023Article
- Bacterial ribonucleases and their roles in RNA metabolism.Critical reviews in biochemistry and molecular biology · 2019Review
- Distributive enzyme binding controlled by local RNA context results in 3' to 5' directional processing of dicistronic tRNA precursors by Escherichia coli ribonuclease P.Nucleic acids research · 2019Article
- Bacterial transfer RNAs.FEMS microbiology reviews · 2015Review
- Small stable RNA maturation and turnover in Bacillus subtilis.Molecular microbiology · 2015Article
- Essential is not irreplaceable: fitness dynamics of experimental E. coli RNase P RNA heterologous replacement.Journal of molecular evolution · 2014Article
- Transcriptional cross-regulation between Gram-negative and gram-positive bacteria, demonstrated using ArgP-argO of Escherichia coli and LysG-lysE of Corynebacterium glutamicum.Journal of bacteriology · 2012Article
- Downward causation by information control in micro-organisms.Interface focus · 2012Article
- Of proteins and RNA: the RNase P/MRP family.RNA (New York, N.Y.) · 2010Review
- Initiation of decay of Bacillus subtilis rpsO mRNA by endoribonuclease RNase Y.Journal of bacteriology · 2010Article
- The ancient history of the structure of ribonuclease P and the early origins of Archaea.BMC bioinformatics · 2010Article
- Binding of C5 protein to P RNA enhances the rate constant for catalysis for P RNA processing of pre-tRNAs lacking a consensus (+ 1)/C(+ 72) pair.Journal of molecular biology · 2010Article
- In vivo display of a multisubunit enzyme complex on biogenic magnetic nanoparticles.Applied and environmental microbiology · 2009Article
- Investigation of catalysis by bacterial RNase P via LNA and other modifications at the scissile phosphodiester.Nucleic acids research · 2009Article
- Top-down causation by information control: from a philosophical problem to a scientific research programme.Journal of the Royal Society, Interface · 2008Article
- Erythromycin-induced ribosome stalling and RNase J1-mediated mRNA processing in Bacillus subtilis.Molecular microbiology · 2008Article
- RNase P cleaves the adenine riboswitch and stabilizes pbuE mRNA in Bacillus subtilis.RNA (New York, N.Y.) · 2008Article
- OLE RNA, an RNA motif that is highly conserved in several extremophilic bacteria, is a substrate for and can be regulated by RNase P RNA.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Probing the architecture of the B. subtilis RNase P holoenzyme active site by cross-linking and affinity cleavage.RNA (New York, N.Y.) · 2007Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We show that structural type A and B bacterial ribonuclease P (RNase P) RNAs can fully replace each other in vivo despite the many reported differences in their biogenesis, biochemical/biophysical properties and enzyme function in vitro. Our findings suggest that many of the reported idiosyncrasies of type A and B enzymes either do not reflect the in vivo situation or are not crucial for RNase P function in vivo, at least under standard growth conditions. The discrimination of mature tRNA by RNase P, so far thought to prevent product inhibition of the enzyme in the presence of a large cellular excess of mature tRNA relative to the precursor form, is apparently not crucial for RNase P function in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.