ReviewJournal of clinical hypertension (Greenwich, Conn.)2006
Management strategies for patients with hypertension and diabetes: why combination therapy is critical.
Review in Journal of clinical hypertension (Greenwich, Conn.), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Initial combination therapy compared with monotherapy in diabetic hypertensive patients.Journal of clinical hypertension (Greenwich, Conn.) · 2008Trial
- Blood pressure, glycemic control, and white matter hyperintensity progression in type 2 diabetics.Neurology · 2019Article
- Aggressive blood pressure-lowering therapy guided by home blood pressure monitoring improves target organ damage in hypertensive patients with type 2 diabetes/prediabetes.Journal of clinical hypertension (Greenwich, Conn.) · 2012Article
- Article
- Current concepts in combination therapy for the treatment of hypertension: combined calcium channel blockers and RAAS inhibitors.Integrated blood pressure control · 2009Article
- Effective management of hypertension with dihydropyridine calcium channel blocker-based combination therapy in patients at high cardiovascular risk.International journal of clinical practice · 2008Review
- Patterns and associated health services costs of antihypertensive drug modifications.Journal of clinical hypertension (Greenwich, Conn.) · 2008Article
- Emerging insights in the first-step use of antihypertensive combination therapy.Journal of clinical hypertension (Greenwich, Conn.) · 2007Review
Corrections and comments
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Authors and funding
2 authors.
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Abstract
Hypertension is commonly associated and acts synergistically with diabetes in increasing the risk of macrovascular and microvascular diabetic complications. Large-scale clinical trials have demonstrated that this risk is significantly reduced by intensive antihypertensive treatment, and accordingly, the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure guideline has further lowered the blood pressure goals for diabetic subjects to <130/80 mm Hg. This implies that most diabetic patients will require the combination of two or more antihypertensive agents to achieve this blood pressure target. Although the most effective combination strategy in diabetes has not yet been determined in large-scale randomized clinical trials, a combination that includes at least one agent that interrupts the renin-angiotensin system appears to not only have a good safety profile, but may also provide additional renal and cardiovascular protection. Other antihypertensive agents should be added based on the patients risk profile and overall treatment regimen to achieve blood pressure goal.
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