ArticleBlood2006
Uncoupling of T-cell effector functions by inhibitory killer immunoglobulin-like receptors.
Article in Blood, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 57 citations in OpenAlex.
- Fusing data from CT deep learning, CT radiomics and peripheral blood immune profiles to diagnose lung cancer in a cohort of patients experiencing symptoms.EBioMedicine · 2026Article
- Antigen-experienced NK-T cells: integrating new insights and exploring therapeutic potential in cancer immunotherapy.Frontiers in immunology · 2026Review
- Inhibitory KIRs decrease HLA class II-mediated protection in Type 1 Diabetes.PLoS genetics · 2024Article
- Heterogeneity of memory T cells in aging.Frontiers in immunology · 2023Review
- Immunogenomics of Killer Cell Immunoglobulin-Like Receptor (KIR) and HLA Class I: Coevolution and Consequences for Human Health.The journal of allergy and clinical immunology. In practice · 2022Article
- Molecular Mechanisms of T Cells Activation by Dendritic Cells in Autoimmune Diseases.Frontiers in pharmacology · 2018Review
- Successful and Maladaptive T Cell Aging.Immunity · 2017Review
- Deciphering the killer-cell immunoglobulin-like receptor system at super-resolution for natural killer and T-cell biology.Immunology · 2017Review
- Immune Checkpoint Function of CD85j in CD8 T Cell Differentiation and Aging.Frontiers in immunology · 2017Article
- The life cycle of a T cell after vaccination - where does immune ageing strike?Clinical and experimental immunology · 2017Review
- Oxidative stress and age-related changes in T cells: is thalassemia a model of accelerated immune system aging?Central-European journal of immunology · 2016Review
- BTLA marks a less-differentiated tumor-infiltrating lymphocyte subset in melanoma with enhanced survival properties.Oncoimmunology · 2015Article
- Multiplex and genome-wide analyses reveal distinctive properties of KIR+ and CD56+ T cells in human blood.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Naive T-cells in myelodysplastic syndrome display intrinsic human telomerase reverse transcriptase (hTERT) deficiency.Leukemia · 2013Article
- Controlling natural killer cell responses: integration of signals for activation and inhibition.Annual review of immunology · 2013Review
- The janus head of T cell aging - autoimmunity and immunodeficiency.Frontiers in immunology · 2013Article
- CD8 T cells express randomly selected KIRs with distinct specificities compared with NK cells.Blood · 2012Article
- Signaling pathways in aged T cells - a reflection of T cell differentiation, cell senescence and host environment.Seminars in immunology · 2012Review
- Quantitative phosphoproteomics reveals SLP-76 dependent regulation of PAG and Src family kinases in T cells.PloS one · 2012Article
- Finding Balance: T cell Regulatory Receptor Expression during Aging.Aging and disease · 2011Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Killer immunoglobulin-like receptors (KIRs) are a family of regulatory cell-surface molecules expressed on natural killer (NK) cells and memory T-cell subsets. Their ability to prevent the formation of an activation platform and to inhibit NK cell activation is the basis of the missing self model of NK cell function. The benefits of KIR expression for T-cell biology are unclear. We studied how KIR2DL2 regulates T-cell function. Engagement of KIR2DL2 by the ligand human leukocyte antigen (HLA)-Cw3 did not affect conjugate formation between CD4(+)KIR2DL2(+) T cells and superantigen-pulsed target cells or the development of mature immune synapses with lipid rafts. KIR2DL2 and the corresponding HLA-C ligand were initially recruited to the peripheral supramolecular activation cluster (pSMAC). Consequently, KIR2DL2 engagement did not inhibit the phosphorylation of early signaling proteins and T-cell-receptor (TCR)-mediated cytotoxicity or granule exocytosis. After 15-30 minutes, KIR2DL2 moved to the central supramolecular activation cluster (cSMAC), colocalizing with CD3. TCR synapses dissociated, and phosphorylated phospholipase C (PLC)-gamma1, Vav1, and extracellular signal-regulated kinase 1/2 (ERK1/2) were reduced 90 minutes after stimulation. Gene array studies documented that the inhibition of late signaling events by KIR2DL2 affected transcriptional gene activation. We propose that KIRs on memory T cells operate to uncouple effector functions by modifying the transcriptional profile while leaving granule exocytosis unabated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.