ReviewJournal of inorganic biochemistry2006
Oxidative dealkylation DNA repair mediated by the mononuclear non-heme iron AlkB proteins.
Review in Journal of inorganic biochemistry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 74 citations in OpenAlex.
- Electronic Structure Contributions to the Reactivity of Mononuclear FeAccounts of chemical research · 2026Article
- AlkD's Conformational Dynamics Regulated by Protein-DNA Interactions for Effective Target Recognition.The journal of physical chemistry letters · 2025Article
- Experimental electronic structures of the FeProceedings of the National Academy of Sciences of the United States of America · 2025Article
- X-ray Spectroscopic Study of the Electronic Structure of a Trigonal High-Spin Fe(IV)═O Complex Modeling Non-Heme Enzyme Intermediates and Their Reactivity.Journal of the American Chemical Society · 2023Article
- Visible light-induced oxidativeChemical science · 2021Article
- DNA Demethylation in the Processes of Repair and Epigenetic Regulation Performed by 2-Ketoglutarate-Dependent DNA Dioxygenases.International journal of molecular sciences · 2021Review
- Demethyltransferase AlkBH1 substrate diversity and relationship to human diseases.Molecular biology reports · 2021Review
- Emerging Roles of N6-Methyladenosine (m6A) Epitranscriptomics in Toxicology.Toxicological sciences : an official journal of the Society of Toxicology · 2021Article
- A high-throughput screening method for evolving a demethylase enzyme with improved and new functionalities.Nucleic acids research · 2021Article
- Nuclear Resonance Vibrational Spectroscopic Definition of the Facial Triad FeJournal of the American Chemical Society · 2020Article
- Evaluation of a concerted vs. sequential oxygen activation mechanism in α-ketoglutarate-dependent nonheme ferrous enzymes.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- The response of Escherichia coli to the alkylating agents chloroacetaldehyde and styrene oxide.Mutation research. Genetic toxicology and environmental mutagenesis · 2019Article
- Selective base excision repair of DNA damage by the non-base-flipping DNA glycosylase AlkC.The EMBO journal · 2018Article
- Mechanism of error-free DNA synthesis across N1-methyl-deoxyadenosine by human DNA polymerase-ι.Scientific reports · 2017Article
- Structure and Mechanism of a Viral Collagen Prolyl Hydroxylase.Biochemistry · 2015Article
- TET family proteins: oxidation activity, interacting molecules, and functions in diseases.Chemical reviews · 2015Review
- Alternative Pathway for the Reaction Catalyzed by DNA Dealkylase AlkB from Ab Initio QM/MM Calculations.Journal of chemical theory and computation · 2014Article
- Homology modeling, molecular dynamics, and site-directed mutagenesis study of AlkB human homolog 1 (ALKBH1).Journal of molecular graphics & modelling · 2014Article
- Nucleic acid oxidation in DNA damage repair and epigenetics.Chemical reviews · 2014Review
- Quantum mechanics/molecular mechanics study on the oxygen binding and substrate hydroxylation step in AlkB repair enzymes.Chemistry (Weinheim an der Bergstrasse, Germany) · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
DNA can be damaged by various intracellular and environmental alkylating agents to produce alkylation base lesions. These base damages, if not repaired promptly, may cause genetic changes that lead to diseases such as cancer. Recently, it was discovered that some of the alkylation DNA base damage can be directly removed by a family of proteins called the AlkB proteins that utilize a mononuclear non-heme iron(II) and alpha-ketoglutarate as cofactor and cosubstrate. These proteins activate dioxygen and perform an unprecedented oxidative dealkylation of the alkyl adducts on DNA heteroatoms. This review summarizes the discovery of this activity and the recent research advances in studying this unique DNA repair pathway. The focus is placed on the chemical mechanism and function of these proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.