ArticleVirology2006
The effect of genome length on ejection forces in bacteriophage lambda.
Article in Virology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed.
- Something old, something new? Herpesvirus genome packaging examined in light of lessons from the tailed bacteriophages.Journal of virology · 2026Review
- Structure of Stacked Aggregates of Semiflexible Rings Under Spherical Confinement: A Computational Study.Polymers · 2026Article
- Understanding the Mechanism of Bent DNA Amplifying Sensors Using All-Atom Molecular Dynamics Simulations.Biosensors · 2025Article
- Coinfecting phages impede each other's entry into the cell.Current biology : CB · 2024Article
- Article
- 'SAXS-osmometer' method provides measurement of DNA pressure in viral capsids and delivers an empirical equation of state.Nucleic acids research · 2023Article
- A tradeoff between enterovirus A71 particle stability and cell entry.Nature communications · 2023Article
- AT-specific DNA visualization revisits the directionality of bacteriophage λ DNA ejection.Nucleic acids research · 2023Article
- Recombinant Reporter Phage rTUN1::ACS sensors · 2023Article
- Nucleus size and its effect on nucleosome stability in living cells.Biophysical journal · 2022Article
- A general theory of polymer ejection tested in a quasi two-dimensional space.Scientific reports · 2021Article
- Evolution of the Free Energy Landscapes ofThe journal of physical chemistry. B · 2021Article
- Scaling relation between genome length and particle size of viruses provides insights into viral life history.iScience · 2021Article
- Article
- Article
- Pressure-driven release of viral genome into a host nucleus is a mechanism leading to herpes infection.eLife · 2019Article
- Influence of Microscopic Interactions on the Flexible Mechanical Properties of Viral DNA.Biophysical journal · 2018Article
- Experimental comparison of forces resisting viral DNA packaging and driving DNA ejection.Physical review. E · 2017Article
- Structure of a headful DNA-packaging bacterial virus at 2.9 Å resolution by electron cryo-microscopy.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
A variety of viruses tightly pack their genetic material into protein capsids that are barely large enough to enclose the genome. In particular, in bacteriophages, forces as high as 60 pN are encountered during packaging and ejection, produced by DNA bending elasticity and self-interactions. The high forces are believed to be important for the ejection process, though the extent of their involvement is not yet clear. As a result, there is a need for quantitative models and experiments that reveal the nature of the forces relevant to DNA ejection. Here, we report measurements of the ejection forces for two different mutants of bacteriophage lambda, lambdab221cI26 and lambdacI60, which differ in genome length by approximately 30%. As expected for a force-driven ejection mechanism, the osmotic pressure at which DNA release is completely inhibited varies with the genome length: we find inhibition pressures of 15 atm and 25 atm, for the short and long genomes, respectively, values that are in agreement with our theoretical calculations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.