ArticleBMC evolutionary biology2006
Evolution of the NANOG pseudogene family in the human and chimpanzee genomes.
Article in BMC evolutionary biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 46 citations in OpenAlex.
- NANOGP1, a tandem duplicate of NANOG, exhibits partial functional conservation in human naïve pluripotent stem cells.Development (Cambridge, England) · 2023Article
- A Restriction Endonuclease-Based Assay to Distinguish NANOGP8 Retrogene from Parental NANOG.Methods in molecular biology (Clifton, N.J.) · 2021Article
- NANOGP8 expression regulates gastric cancer cell progression by transactivating DBC1 in gastric cancer MKN-45 cells.Oncology letters · 2019Article
- Immune Curbing of Cancer Stem Cells by CTLs Directed to NANOG.Frontiers in immunology · 2018Article
- A sister ofOpen biology · 2017Article
- Silencing expression of the NANOG gene and changes in migration and metastasis of urinary bladder cancer cells.Archives of medical science : AMS · 2016Article
- Insights into theInternational journal of biological sciences · 2016Review
- The role of NANOG transcriptional factor in the development of malignant phenotype of cancer cells.Cancer biology & therapy · 2016Review
- Comparative analysis of pseudogenes across three phyla.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- An expressed retrogene of the master embryonic stem cell gene POU5F1 is associated with prostate cancer susceptibility.American journal of human genetics · 2014Article
- On the origin and evolutionary history of NANOG.PloS one · 2014Article
- NANOGP8: evolution of a human-specific retro-oncogene.G3 (Bethesda, Md.) · 2012Article
- Homeobox genes in obsessive-compulsive disorder.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2012Article
- Transcriptional properties of human NANOG1 and NANOG2 in acute leukemic cells.Nucleic acids research · 2010Article
- High divergence in primate-specific duplicated regions: human and chimpanzee chorionic gonadotropin beta genes.BMC evolutionary biology · 2008Article
- Classification and nomenclature of all human homeobox genes.BMC biology · 2007Article
- Structural divergence between the human and chimpanzee genomes.Human genetics · 2007Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe NANOG gene is expressed in mammalian embryonic stem cells where it maintains cellular pluripotency. An unusually large family of pseudogenes arose from it with one unprocessed and ten processed pseudogenes in the human genome. This article compares the NANOG gene and its pseudogenes in the human and chimpanzee genomes and derives an evolutionary history of this pseudogene family.
resultsThe NANOG gene and all pseudogenes except NANOGP8 are present at their expected orthologous chromosomal positions in the chimpanzee genome when compared to the human genome, indicating that their origins predate the human-chimpanzee divergence. Analysis of flanking DNA sequences demonstrates that NANOGP8 is absent from the chimpanzee genome.
conclusionBased on the most parsimonious ordering of inferred source-gene mutations, the deduced evolutionary origins for the NANOG pseudogene family in the human and chimpanzee genomes, in order of most ancient to most recent, are NANOGP6, NANOGP5, NANOGP3, NANOGP10, NANOGP2, NANOGP9, NANOGP7, NANOGP1, and NANOGP4. All of these pseudogenes were fixed in the genome of the human-chimpanzee common ancestor. NANOGP8 is the most recent pseudogene and it originated exclusively in the human lineage after the human-chimpanzee divergence. NANOGP1 is apparently an unprocessed pseudogene. Comparison of its sequence to the functional NANOG gene's reading frame suggests that this apparent pseudogene remained functional after duplication and, therefore, was subject to selection-driven conservation of its reading frame, and that it may retain some functionality or that its loss of function may be evolutionarily recent.
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