ArticleBMC urology2006
Inflammation and enhanced nociceptive responses to bladder distension produced by intravesical zymosan in the rat.
Article in BMC urology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- Animal Models of Hunner-Type Interstitial Cystitis.International journal of urology : official journal of the Japanese Urological Association · 2026Review
- Neonatal Cystitis Makes Adult Female Rat Urinary Bladders More Sensitive to Low Concentration Microbial Antigens.Research and reports in urology · 2023Article
- Animal models of interstitial cystitis/bladder pain syndrome.Frontiers in physiology · 2023Review
- Article
- A Model in Female Rats With Phenotypic Features Similar to Interstitial Cystitis/Bladder Pain Syndrome.Frontiers in pain research (Lausanne, Switzerland) · 2021Article
- Functional activities of beta-glucans in the prevention or treatment of cervical cancer.Journal of ovarian research · 2020Review
- Vaginal hypersensitivity and hypothalamic-pituitary-adrenal axis dysfunction as a result of neonatal maternal separation in female mice.Neuroscience · 2014Article
- Visceral pain: the ins and outs, the ups and downs.Current opinion in supportive and palliative care · 2012Review
- Article
- Effects of acute adult and early-in-life bladder inflammation on bladder neuropeptides in adult female rats.BMC urology · 2011Article
- Neonatal cystitis-induced colonic hypersensitivity in adult rats: a model of viscero-visceral convergence.Neurogastroenterology and motility · 2011Article
- Footshock stress differentially affects responses of two subpopulations of spinal dorsal horn neurons to urinary bladder distension in rats.Brain research · 2011Article
- All-trans-retinoic acid and Erk1/2 signaling synergistically regulate the expression of CD300B in human monocytic cells.Cellular immunology · 2011Article
- Neonatal bladder inflammation alters activity of adult rat spinal visceral nociceptive neurons.Neuroscience letters · 2010Article
- Neonatal bladder inflammation produces functional changes and alters neuropeptide content in bladders of adult female rats.The journal of pain · 2010Article
- Effect of estrogen on bladder nociception in rats.The Journal of urology · 2010Article
- Acute bladder inflammation differentially affects rat spinal visceral nociceptive neurons.Neuroscience letters · 2009Article
- Visceral pain: the neurophysiological mechanism.Handbook of experimental pharmacology · 2009Review
- Footshock-induced urinary bladder hypersensitivity: role of spinal corticotropin-releasing factor receptors.The journal of pain · 2008Article
- Rostral ventral medulla modulation of the visceromotor reflex evoked by urinary bladder distension in female rats.The journal of pain · 2008Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundMycotic infections of the bladder produce pain and inflammatory changes. The present study examined the inflammatory and nociceptive effects of the yeast cell wall component, zymosan, when administered into the urinary bladder in order to characterize this form of bladder sensitization.
methodsParametric analyses of the time-course (0-48 hr) and concentration (0-2% solutions) variables associated with intravesical zymosan-induced bladder inflammation were performed in female rats. Plasma extravasation of Evan's Blue dye was used as a measure of tissue inflammation. Cardiovascular and visceromotor responses to urinary bladder distension were used as measures of nociception.
resultsZymosan-induced bladder inflammation, as indexed by plasma extravasation of Evan's Blue, was significantly greater in rats treated with either 1 or 2% solutions as compared to either 0.1 or 0.5% zymosan solutions. In time-course studies (1-48 hr post-treatment), 1% zymosan-induced inflammation progressively increased with time following administration, was greatest at 24 hr and began to normalize by 48 hr. In the studies of inflammation-induced changes in nociception, arterial blood pressure (ABP) and visceromotor responses to graded distension of the urinary bladder were significantly increased relative to controls 24 hr after zymosan administration.
conclusionThese studies provide important time-course and solution concentration parameters for studies of zymosan-induced inflammation of the bladder and suggest utility of this model for the study of bladder-related pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.