Trial reportEuropean journal of applied physiology2006
RAAS polymorphisms alter the acute blood pressure response to aerobic exercise among men with hypertension.
Trial report in European journal of applied physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Effect of supervised exercise training on cardiovascular function in patients with intermittent claudication: a systematic review and meta-analysis of randomized controlled trials.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Pooled it
- Acute Effects of Exercise on Blood Pressure: A Meta-Analytic Investigation.Arquivos brasileiros de cardiologia · 2016Pooled it
- Effect of exercise training on the renin-angiotensin-aldosterone system in healthy individuals: a systematic review and meta-analysis.Hypertension research : official journal of the Japanese Society of Hypertension · 2016Pooled it
- Efficacy of Unsupervised YouTube Dance Exercise for Patients With Hypertension: Randomized Controlled Trial.JMIR cardio · 2025Trial
- Hypotensive response magnitude and duration in hypertensives: continuous and interval exercise.Arquivos brasileiros de cardiologia · 2015Trial
- Association of cardiovascular response to an acute resistance training session with the ACE gene polymorphism in sedentary women: a randomized trial.BMC cardiovascular disorders · 2013Trial
- The metabolic syndrome and the immediate antihypertensive effects of aerobic exercise: a randomized control design.BMC cardiovascular disorders · 2008Trial
- Effects of Acute Aquatic High-Intensity Intermittent Exercise on Blood Pressure and Arterial Stiffness in Postmenopausal Women with Different ACE Genotypes.International journal of environmental research and public health · 2022Article
- Association Between Hospital Anxiety Depression Scale and Autonomic Recovery Following Exercise.Journal of clinical psychology in medical settings · 2020Article
- Sinapine Thiocyanate Ameliorates Vascular Endothelial Dysfunction in Hypertension by Inhibiting Activation of the NLRP3 Inflammasome.Frontiers in pharmacology · 2020Article
- Acute Post-Exercise Blood Pressure Responses in Middle-Aged Persons with Elevated Blood Pressure/Stage 1 Hypertension following Moderate and High-Intensity Isoenergetic Endurance Exercise.International journal of exercise science · 2020Article
- Review
- FURIN variant associations with postexercise hypotension are intensity and race dependent.Physiological reports · 2019Article
- Angiotensin II Type 1 Receptor Gene A1166C Polymorphism Was Not Associated With Acute Coronary Syndrome in an Iranian Population.Iranian Red Crescent medical journal · 2016Article
- Deep-targeted exon sequencing reveals renal polymorphisms associate with postexercise hypotension among African Americans.Physiological reports · 2016Article
- Neuro-hormonal effects of physical activity in the elderly.Frontiers in physiology · 2013Review
- Acute and chronic effects of resistance exercise on blood pressure in elderly women and the possible influence of ACE I/D polymorphism.International journal of general medicine · 2013Article
- The magnitude and duration of post-exercise hypotension after land and water exercises.European journal of applied physiology · 2012Article
- Modulation of catecholamine-synthesizing enzymes in adrenal medulla and stellate ganglia by treadmill exercise of stressed rats.European journal of applied physiology · 2012Article
- The higher exercise intensity and the presence of allele I of ACE gene elicit a higher post-exercise blood pressure reduction and nitric oxide release in elderly women: an experimental study.BMC cardiovascular disorders · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Limited evidence suggests renin-angiotensin-aldosterone system (RAAS) polymorphisms alter the blood pressure (BP) response to aerobic exercise training. We examined if RAAS polymorphisms influenced postexercise hypotension in men with high normal to Stage 1 hypertension. Forty-seven men (44.2+/-1.4 years, 145.1+/-1.6/85.5+/-1.1 mmHg) randomly completed three experiments: seated rest (control) and two cycle exercise bouts at 40% (LITE) and 60% (MOD) of maximal oxygen consumption. Ambulating BP was measured for 14 h after each experiment. RAAS polymorphisms associated with hypertension (i.e. angiotensin converting I enzyme, ACE I/D; angiotensin II type 1 receptor, AT1R A/C; and intron 2 of aldosterone synthase, Int2 W/C) were analyzed using polymerase chain reaction and restriction enzyme digestion. Repeated measure ANOVA tested if BP differed between experimental conditions by RAAS genotypes. Compared to men with 0-2 variant alleles, men with > or =3 combined RAAS variant alleles had lower average systolic BP (SBP) (P=0.030) and lower average diastolic BP (DBP) (P=0.009) for 14 h only after LITE. In contrast, average BP was not different for MOD and control between RAAS variant allele groups over this time period (P> or =0.05). LITE reduced BP in men with > or =3 variant RAAS alleles for 14 h, whereas MOD had no influence on BP in these men. In order to optimally prescribe exercise for its BP lowering benefits in those with hypertension, additional knowledge of how genetic variation affects the BP response to exercise is needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.