ArticleJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology2006
Transport of acetate and sodium in sheep omasum: mutual, but asymmetric interactions.
Article in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 19 citations in OpenAlex.
- Carbonic anhydrase influences asymmetric sodium and acetate transport across omasum of sheep.Animal bioscience · 2021Article
- Establishment and identification of primary bovine omasal epithelial cells.In vitro cellular & developmental biology. Animal · 2020Article
- Potential Role of SLC5A8 Expression in the Etiology of Subacute Ruminal Acidosis.Frontiers in veterinary science · 2020Article
- Effect of exogenous butyrate on the gastrointestinal tract of sheep. I. Structure and function of the rumen, omasum, and abomasum.Journal of animal science · 2018Article
- Epithelia of the ovine and bovine forestomach express basolateral maxi-anion channels permeable to the anions of short-chain fatty acids.Pflugers Archiv : European journal of physiology · 2014Article
- Article
- Absorption of short-chain fatty acids, sodium and water from the forestomach of camels.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2007Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have studied the transport of acetate across the isolated epithelium of sheep omasum; no net transport was observed (J(ms) approximately = J(sm)) under Ussing chamber conditions. Low mucosal pH (pH 6.4) significantly enhanced J(ms) acetate and the transport rates of acetate increased linearly and significantly (r2=0.99) with the luminal acetate concentration. The presence of another short chain fatty acid (propionate) did not affect J(ms) acetate significantly. Neither addition of 1 mmol l(-1) DIDS to the mucosal side nor HCO3 replacement caused changes of J(ms) acetate; this does not support the assumption of acetate transport via anion exchange. Addition of 1 mmol l(-1) amiloride to the mucosal side significantly decreased acetate fluxes at high mucosal acetate concentration (100 mmol l(-1)) and low pH (6.4) indicating interaction between acetate uptake in the undissociated form, intracellular release of protons and activation of Na+/H+ exchange (NHE). However, the mutual interaction between Na transport via NHE and acetate transport is asymmetric. Stimulation or inhibition of Na transport via NHE is much more pronounced than the corresponding changes of acetate fluxes. Thus, the obtained results support the conclusion that acetate is transported via simple diffusion and probably predominantly in the protonated form, thereby explaining the positive and mutual interaction between Na transport and short chain fatty acids.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.