ArticleCurrent genetics2006
Comparative analysis of HOG pathway proteins to generate hypotheses for functional analysis.
Article in Current genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Comparative Genomics Analysis of the Fish Pathogen Rahnella aquatilis KCL-5 Reveals Potential Multidrug Resistance and Virulence Properties.Current microbiology · 2025Article
- Intrinsically disordered signaling proteins: Essential hub players in the control of stress responses in Saccharomyces cerevisiae.PloS one · 2022Article
- Sensing and Responding to Hypersaline Conditions and the HOG Signal Transduction Pathway in Fungi Isolated from Hypersaline Environments:Journal of fungi (Basel, Switzerland) · 2021Review
- Molecular cloning and sequence analysis of a mitogen-activated protein kinase gene in the Antarctic yeast Rhodotorula mucilaginosa AN5.Molecular biology reports · 2021Article
- Transcriptional regulation of the caspofungin-induced cell wall damage response in Candida albicans.Current genetics · 2020Review
- Acetylation of BcHpt Lysine 161 RegulatesFrontiers in microbiology · 2019Article
- Short linear motifs in intrinsically disordered regions modulate HOG signaling capacity.BMC systems biology · 2018Article
- ChSte7 Is Required for Vegetative Growth and Various Plant Infection Processes in Colletotrichum higginsianum.BioMed research international · 2016Article
- Reconstruction of the High-Osmolarity Glycerol (HOG) Signaling Pathway from the Halophilic Fungus Wallemia ichthyophaga in Saccharomyces cerevisiae.Frontiers in microbiology · 2016Article
- The response regulator BcSkn7 is required for vegetative differentiation and adaptation to oxidative and osmotic stresses in Botrytis cinerea.Molecular plant pathology · 2015Article
- Article
- The HOG signal transduction pathway in the halophilic fungus Wallemia ichthyophaga: identification and characterisation of MAP kinases WiHog1A and WiHog1B.Extremophiles : life under extreme conditions · 2013Article
- Response to hyperosmotic stress.Genetics · 2012Review
- Multiple roles of Ypd1 phosphotransfer protein in viability, stress response, and virulence factor regulation in Cryptococcus neoformans.Eukaryotic cell · 2011Article
- Involvement of a putative response regulator FgRrg-1 in osmotic stress response, fungicide resistance and virulence in Fusarium graminearum.Molecular plant pathology · 2011Article
- The MAPKK kinase ChSte11 regulates sexual/asexual development, melanization, pathogenicity, and adaptation to oxidative stress in Cochliobolus heterostrophus.Current genetics · 2009Article
- Msb2 signaling mucin controls activation of Cek1 mitogen-activated protein kinase in Candida albicans.Eukaryotic cell · 2009Article
- Involvement of putative response regulator genes of the rice blast fungus Magnaporthe oryzae in osmotic stress response, fungicide action, and pathogenicity.Current genetics · 2008Article
- Regulation of the Candida albicans cell wall damage response by transcription factor Sko1 and PAS kinase Psk1.Molecular biology of the cell · 2008Article
- Signal processing by the HOG MAP kinase pathway.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
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Authors and funding
3 authors.
Funding
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Abstract
Comparative genomics allows comparison of different proteins that execute presumably identical functions in different organisms. In contrast to paralogues, orthologues per definition perform the same function and interact with the same partners and, consequently, should display conservation in all these properties. We have employed 20 fungal genomes to analyse key components of the high osmolarity glycerol signalling pathway of Saccharomyces cerevisiae. Among the proteins scrutinised are a complete phosphotransfer module, a MAP kinase, two scaffold proteins, one of which is also a MAPKK, and two transcription factors. Sequence alignments, domain structure and size analysis, combined with the rich information available in the literature, allowed us to probe previous structural and functional studies and to generate hypotheses for future experimental studies. Although certain domains are too highly conserved across fungal species for meaningful comparative studies, others, like interaction domains, can be studied in closely related species. Moreover, putative functionally relevant sites for protein modifications can be identified in such comparative studies. We provide several relevant examples and present a number of previously un(der)characterised domains of potential functional significance in osmosensing and signal transduction. We propose that any functional protein analysis in fungi should make use of the unique resource that fungal genome sequences offer.
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