ArticleImmunogenetics2006
Duplication, balancing selection and trans-species evolution explain the high levels of polymorphism of the DQA MHC class II gene in voles (Arvicolinae).
Article in Immunogenetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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34 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.
- Meta-analysis of major histocompatibility complex (MHC) class IIA reveals polymorphism and positive selection in many vertebrate species.Molecular ecology · 2022Pooled it
- Evolutionary trade-offs constraining the MHC gene expansion: beyond simple TCR depletion model.Frontiers in immunology · 2023Article
- Long term patterns of association between MHC and helminth burdens in the bank vole support Red Queen dynamics.Molecular ecology · 2022Article
- Genetic diversity, evolution and selection in the major histocompatibility complex DRB and DQB loci in the family Equidae.BMC genomics · 2020Article
- Comparative analysis of host resistance to Sarcoptes scabiei var. cuniculi in two different rabbit breeds.Parasites & vectors · 2019Article
- Major histocompatibility complex class I diversity limits the repertoire of T cell receptors.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Molecular Cloning and Bioinformatics Analysis ofInternational journal of molecular sciences · 2019Article
- Profiling of the TCRβ repertoire in non-model species using high-throughput sequencing.Scientific reports · 2018Article
- Article
- Molecular characterization of MHC class IIB genes of sympatric Neotropical cichlids.BMC genetics · 2017Article
- Evidence for selection maintaining MHC diversity in a rodent species despite strong density fluctuations.Immunogenetics · 2016Article
- Genetic diversity comparison of the DQA gene in European rabbit (Oryctolagus cuniculus) populations.Immunogenetics · 2015Article
- Positive selection on MHC class II DRB and DQB genes in the bank vole (Myodes glareolus).Journal of molecular evolution · 2014Article
- Contrasted evolutionary histories of two Toll-like receptors (Tlr4 and Tlr7) in wild rodents (MURINAE).BMC evolutionary biology · 2013Article
- Duplication and population dynamics shape historic patterns of selection and genetic variation at the major histocompatibility complex in rodents.Ecology and evolution · 2013Article
- Signatures of balancing selection are maintained at disease resistance loci following mating system evolution and a population bottleneck in the genus Capsella.BMC evolutionary biology · 2012Article
- Independent evolution of functional MHC class II DRB genes in New World bat species.Immunogenetics · 2012Article
- Evolutionary genetics of MHC class II beta genes in the brown hare, Lepus europaeus.Immunogenetics · 2011Article
- The functional gene diversity in natural populations over postglacial areas: the shaping mechanisms behind genetic composition of longnose dace (Rhinichthys cataractae) in northeastern North America.Journal of molecular evolution · 2011Article
- Adaptive molecular evolution of the Major Histocompatibility Complex genes, DRA and DQA, in the genus Equus.BMC evolutionary biology · 2011Article
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Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Major histocompatibility complex (MHC) genes play important role in host-parasite interactions and parasites are crucial factors influencing the population dynamics of hosts. We described the structure and diversity of exon 2 of the MHC class II DQA gene in three species of voles (Arvicolinae) exhibiting regular multi-annual fluctuations of population density and analysed the processes leading to the observed MHC polymorphism. By using cloning-sequencing methodology and capillary electrophoresis-single strand conformation polymorphism, we described seven sequences in the water, eight in the common, and seven in the bank voles coming from an area of 70 km(2) around the Nozeroy canton in the Jura Mountains (Franche Comté, France). All exon 2 sequences translate to give unique amino acid sequences and positive selection was found to act very intensively on antigen binding sites. We documented the presence of recombination at vole DQA region but its importance in generating allelic polymorphism seems to be relatively limited. For the first time within rodents, we documented the duplication of the DQA gene in all three species with both copies being transcriptionally active. Phylogenetic analysis of allelic sequences revealed extensive trans-species polymorphism within the subfamily although no alleles were shared between species in our data set. We discuss possible role of parasites in forming the recent polymorphism pattern of the DQA locus in voles.
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