ArticleJournal of human hypertension2006
Carotid artery intima-media thickness and reactive oxygen species formation by monocytes in hypertensive patients.
Article in Journal of human hypertension, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Monocyte dysregulation: consequences for hepatic infections.Seminars in immunopathology · 2021Review
- Systemic Action of Inflammatory Mediators in Patients with Essential Hypertension and Diastolic Chronic Heart Failure: A Clinical Pathophysiological Study.Pathophysiology : the official journal of the International Society for Pathophysiology · 2020Article
- Sarcoidosis exosomes stimulate monocytes to produce pro-inflammatory cytokines and CCL2.Scientific reports · 2020Article
- Dietary Ethanolic Extract ofOpen access Macedonian journal of medical sciences · 2019Article
- Article
- Rapid on-site dual optical system to measure specific reactive oxygen species (O2-• and OCl-) in a tiny droplet of whole blood.PloS one · 2018Article
- The Physiopathology of Cardiorenal Syndrome: A Review of the Potential Contributions of Inflammation.Journal of cardiovascular development and disease · 2017Review
- Expression of theOxidative medicine and cellular longevity · 2017Article
- Reactive Oxygen Species Imaging in a Mouse Model of Inflammatory Bowel Disease.Molecular imaging and biology · 2016Article
- Lower Superoxide Dismutase 2 (SOD2) Protein Content in Mononuclear Cells Is Associated with Better Survival in Patients with Hemodialysis Therapy.Oxidative medicine and cellular longevity · 2016Article
- Oxidative stress in hypertensive children before and after 1 year of antihypertensive therapy.Pediatric nephrology (Berlin, Germany) · 2012Article
- Reactive oxygen species and dopamine receptor function in essential hypertension.Clinical and experimental hypertension (New York, N.Y. : 1993) · 2009Review
- Effects of an exercise challenge on mobilization and surface marker expression of monocyte subsets in individuals with normal vs. elevated blood pressure.Brain, behavior, and immunity · 2008Article
- Antioxidant protection: yet another function of endothelial progenitor cells?Journal of human hypertension · 2007Article
- New insights into complement C3 and inflammation in hypertension.Journal of human hypertension · 2007Article
- Towards understanding the aetiology and pathophysiology of human hypertension: where are we now?Journal of human hypertension · 2006Article
- Reactive oxygen species production by circulating monocytes: insights from pathophysiology to clinical hypertension.Journal of human hypertension · 2006Article
- The +838 C/G MT2A polymorphism, metals, and the inflammatory/immune response in carotid artery stenosis in elderly people.Molecular medicine (Cambridge, Mass.)Article
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4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Carotid artery intima-media thickness (IMT) is a widely accepted index for assessing atherosclerosis, and is known to be a risk indicator for cardiovascular and cerebrovascular events. Oxidative stress and inflammation are also known to play critical roles in the pathogenesis of vascular events. We studied the association between IMT and inflammatory markers, such as oxidative stress in polymorphonuclear leukocytes (PMNs) and mononuclear cells (MNCs) in 156 patients with essential hypertension. Reactive oxygen species (ROS) formation by PMNs and MNCs was measured by gated flow cytometry. CRP and traditional risk factors, such as age, gender, body mass index, hemoglobin A(1c), and total cholesterol were also measured. The subjects were divided into a plaque group (max-IMT>or=1.1 mm, n=40), and a nonplaque group (max-IMT<1.1 mm, n=116). ROS formation by MNCs was significantly increased in the plaque group when compared with the nonplaque group (P<0.0001). Multiple regression analysis revealed a significant correlation between IMT and ROS formation by MNCs (r=0.407, P<0.0001), or CRP (r=0.216, P=0.0029) or hemoglobinA1c (r=0.158, P=0.0270) or age (r=0.157, P=0.0447). No significant correlation was observed between IMT and ROS formation by PMNs. These results suggest that carotid artery IMT may be affected by increased ROS formation by MNCs, and that increased ROS formation by MNCs may be related to the development of atherosclerosis. We propose that ROS formation by MNCs is a marker for prediction of carotid atherosclerosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.