ArticleThe EMBO journal2006
Vacuolar sequential exocytosis of large dense-core vesicles in adrenal medulla.
Article in The EMBO journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Vesicle docking and fusion pore modulation by the neuronal calcium sensor Synaptotagmin-1.Biophysical journal · 2025Article
- Vesicle docking and fusion pore modulation by the neuronal calcium sensor Synaptotagmin-1.bioRxiv : the preprint server for biology · 2024Article
- Unraveling the mysteries of dendritic spine dynamics: Five key principles shaping memory and cognition.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2023Article
- Article
- Toward a unified picture of the exocytotic fusion pore.FEBS letters · 2018Review
- High Throughput NPY-Venus and Serotonin Secretion Assays for Regulated Exocytosis in Neuroendocrine Cells.Bio-protocol · 2018Article
- Phosphorylation of SNAP-23 regulates its dynamic membrane association during mast cell exocytosis.Biology open · 2017Article
- Differential cargo mobilisation within Weibel-Palade bodies after transient fusion with the plasma membrane.PloS one · 2014Article
- Function suggests nano-structure: electrophysiology supports that granule membranes play dice.Journal of the Royal Society, Interface · 2012Article
- Article
- Loose coupling between calcium channels and sites of exocytosis in chromaffin cells.The Journal of physiology · 2009Article
- Evidence that vesicles undergo compound fusion on the synaptic ribbon.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- A 20-nm step toward the cell membrane preceding exocytosis may correspond to docking of tethered granules.Biophysical journal · 2008Article
- Characterization of sequential exocytosis in a human neuroendocrine cell line using evanescent wave microscopy and "virtual trajectory" analysis.European biophysics journal : EBJ · 2007Article
- Munc18-1: sequential interactions with the fusion machinery stimulate vesicle docking and priming.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Two cAMP-dependent pathways differentially regulate exocytosis of large dense-core and small vesicles in mouse beta-cells.The Journal of physiology · 2007Article
- Influence of quantal size and cAMP on the kinetics of quantal catecholamine release from rat chromaffin cells.Biophysical journal · 2007Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Individual exocytic events in intact adrenal medulla were visualized by two-photon extracellular polar-tracer imaging. Exocytosis of chromaffin vesicles often occurred in a sequential manner, involving first vesicles located at the cell periphery and then those present deeper within the cytoplasm. Sequential exocytosis occurred preferentially at regions of the plasma membrane facing the intercellular space. The compound vesicles swelled to more than five times their original volume and formed vacuolar exocytic lumens as a result of expansion of intravesicular gels and their confinement within the lumen by the fusion pore and the narrow intercellular space. Such luminal swelling greatly promoted sequential exocytosis. The SNARE protein SNAP25 rapidly migrated from the plasma membrane to the membrane of fused vesicles. These data indicate that vesicles present deeper within the cytoplasm can be fusion ready like those at the cell periphery, and that swelling of exocytic lumens promotes assembly of the fusion machinery. We suggest the existence of two molecular configurations for fusion-ready states in Ca2+ -dependent exocytosis.
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